Multilayer based lab-on-a-chip-systems for substance testing

机译：用于物质测试的基于多层的芯片实验室系统

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An integrated technology chain for laser-microstructuring and bonding of polymer foils for fast, flexible and low-cost manufacturing of multilayer lab-on-a-chip devices especially for complex cell and tissue culture applications, which provides pulsatile fluid flow within physiological ranges at low media-to-cells ratio, was developed and established. Initially the microfluidic system is constructively divided into individual layers which are formed by separate foils or plates. Based on the functional boundary conditions and the necessary properties of each layer the corresponding foils and plates are chosen. In the third step the foils and plates are laser microstructured and functionalized from both sides. In the fourth and last manufacturing step the multiple plates and foils are joined using thermal diffusion bonding. Membranes for pneumatically driven valves and micropumps where bonded via chemical surface modification. Based on the established lab-on-a-chip platform for perfused cell-based assays, a multilayer microfluidic system with two parallel connected cell culture chambers was successfully implemented.

机译：用于激光微结构化和粘合聚合物箔的集成技术链，可快速，灵活且低成本地制造多层芯片实验室设备，特别是用于复杂的细胞和组织培养应用，可在生理范围内提供脉动流体制定并确立了低媒体与细胞比率。最初，将微流体系统建设性地分为由单独的箔或板形成的各个层。基于功能边界条件和每一层的必要属性，选择相应的箔和板。在第三步中，将箔和板从两侧进行激光微结构化和功能化。在第四个也是最后一个制造步骤中，使用热扩散粘合将多个板和箔结合在一起。通过化学表面改性粘合的气动阀和微型泵的膜。基于已建立的用于芯片灌注实验的芯片实验室平台，成功实现了具有两个并行连接的细胞培养室的多层微流体系统。

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《Laser-based micro- and nanoprocessing IX》|2015年|93510C.1-93510C.10|共10页
会议地点 San Francisco CA(US)
作者
Frank Sonntag; Stefan Gruenzner; Florian Schmieder; Mathias Busek; Udo Klotzbach; Volker Franke;
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作者单位

Fraunhofer Institute for Material and Beam Technology IWS, Winterbergstr. 28, 01277 Dresden, Germany;

Fraunhofer Institute for Material and Beam Technology IWS, Winterbergstr. 28, 01277 Dresden, Germany;

Fraunhofer Institute for Material and Beam Technology IWS, Winterbergstr. 28, 01277 Dresden, Germany;

Fraunhofer Institute for Material and Beam Technology IWS, Winterbergstr. 28, 01277 Dresden, Germany;

Fraunhofer Institute for Material and Beam Technology IWS, Winterbergstr. 28, 01277 Dresden, Germany;

Fraunhofer Institute for Material and Beam Technology IWS, Winterbergstr. 28, 01277 Dresden, Germany;

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原文格式 PDF
正文语种 eng
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关键词
cell culture; lab-on-a-chip; laser; microstructuring; bonding; micropump; microsystems; perfusion;

机译：细胞培养;芯片实验室激光;微观结构粘接微型泵微系统灌注;

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4. Multilayer based lab-on-a-chip-systems for substance testing [C] . Frank Sonntag, Stefan Gruenzner, Florian Schmieder, Conference on laser-based micro- and nanoprocessing IX . 2015

机译：基于多层的实验室 - 用于物质测试的芯片系统
5. Neuropsychological test norms based on multiple samples: Effects of demographic variables, sample characteristics, and substance use disorders. [D] . Barry, Danielle. 2004

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Multilayer based lab-on-a-chip-systems for substance testing

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