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首页> 外文会议>Laser Medicine and Surgery; Progress in Biomedical Optics and Imaging; vol.6 no.35 >Effect of Intravascular Irradiation of He-Ne Laser on Cerebral Infarction: Hemorrheology and Apoptosis
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Effect of Intravascular Irradiation of He-Ne Laser on Cerebral Infarction: Hemorrheology and Apoptosis

机译：氦氖激光的血管内照射对脑梗死的影响：血液流变学和细胞凋亡

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摘要

Objective: To explore the efficacy of He-Ne laser intravascular irradiation on infarction and hemorrheology. To observe the effects of intravascular low level He-Ne laser irradiation (ILLLI) of blood on cell proliferation, apoptosis and chromosome in lymphocyte from cerebral infarction Methods: Seventy cases with cerebral infarction were randomly divided into groups control group (35 cases) treated only with common drugs and therapeutic group (35 cases) treated besides common drugs also by He-Ne laser intravascular irradiation. Their hemorrheology index and treatment results were observed and compared. The blood lymphocytes of cerebral infarction were cultured before and after treatment. After that, the mitosis index (MI), cell kinetics index (CKI), sister-chromatid exchanges (SCE) frequencies and apoptosis were determined. Results The therapeutic group was better than the control one. The effective rate in the therapeutic group was 88.6%, in the control one was 65.7%. The viscosity and fibrinogen, etc were better than that in the control group with significant difference (P < 0.01). The lymphocyte proliferation index was significantly two increased than the control one (P > 0.05) in cerebral infarction patients after treatment; The CKI of lymphocytes had no obvious difference among groups (P > 0.05); SCE frequencies of lymphocytes had no statistic significance between control group and ILLLI on (P > 0.05). It showed the apoptosis rate of lymphocytes in cerebral infarction patients after ILLLI treatment increased significantly compared with the control group, (P < 0.001). There was a significant difference of apoptosis rate of lymphocytes in cerebral infarction patients than the control (P < 0.001). Conclusions: During the He-Ne laser intravascular irradiation of the cerebral infarction, the low level He-Ne by ILLLI can increase the proliferation of lymphocytes, and can induce lymphocytes to apoptosis, but has no mutagenicity of cells.
机译：目的：探讨氦氖激光血管内照射对梗死和血液流变学的疗效。观察血管内低剂量He-Ne激光辐照对脑梗死淋巴细胞增殖，凋亡和染色体的影响。方法：将70例脑梗死患者随机分为对照组，每组35例。 He-Ne激光血管内照射除常规药物外，共治疗35例。观察并比较他们的血液流变学指标和治疗结果。在治疗前后培养脑梗死的血淋巴细胞。之后，测定有丝分裂指数（MI），细胞动力学指数（CKI），姐妹染色单体交换（SCE）频率和凋亡。结果治疗组优于对照组。治疗组有效率为88.6％，对照组为65.7％。黏度，纤维蛋白原等优于对照组，差异有统计学意义（P <0.01）。治疗后脑梗死患者的淋巴细胞增殖指数比对照组显着提高了2倍（P> 0.05）。各组间淋巴细胞CKI无明显差异（P> 0.05）。对照组和ILLLI组的淋巴细胞SCE频率无统计学意义（P> 0.05）。结果表明，ILLLI治疗后脑梗死患者淋巴细胞凋亡率明显高于对照组（P <0.001）。脑梗死患者淋巴细胞凋亡率与对照组相比差异有统计学意义（P <0.001）。结论：在脑梗死的He-Ne激光血管内照射过程中，ILLLI低水平的He-Ne可以增加淋巴细胞的增殖，并诱导淋巴细胞凋亡，但不具有细胞致突变性。

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