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首页> 外文会议>Laser Medicine and Surgery; Progress in Biomedical Optics and Imaging; vol.6 no.35 >Experimental and Clinical Studies on Transmyocardial Laser Revascularization (TMLR)
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Experimental and Clinical Studies on Transmyocardial Laser Revascularization (TMLR)

机译：经心肌激光血管重建术（TMLR）的实验和临床研究

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摘要

The number of patients with coronary artery disease has been increasing in Japan and several kinds of treatments have been performed to reduce their cardiovascular diseases. In patients with small branches, or diffuse stenotic lesions of the coronary arteries, on whom coronary artery bypass grafting(CABG) and percutaneous coronary intervention (PCI) cannot be carried out, it has been hemodynamically demonstrated possible to supply arterial blood from the left ventricular cavity to the ischemic myocardium through laser channels. On the basis of excellent experimental studies using mongrel dogs, newly created laser channels 0.2 mm in diameter have been confirmed to be histologically patent even 3 years after transmyocardial revascularization(TMLR). Thus, this method could be applied as an alternative procedure of transmyocardial revascularization. First clinical procedure of TMLR alone was performed on 55 year-old male patient with severe angina pectoris who had undergone pericardiectomy 7 years ago. He had no candidate for percutaneous coronary intervention, or coronary artery bypass grafting, because his left venticle had severe adhesion to the left lung. Therefore, this method was finally carried out. He is getting well after this surgical intervention. This procedure should be recommended for the patient with end-stage coronary artery disease.
机译：在日本，冠心病患者的人数一直在增加，并且已经进行了多种治疗以减少其心血管疾病。对于不能进行冠状动脉旁路移植术（CABG）和经皮冠状动脉介入治疗（PCI）的冠状动脉小分支或弥漫性狭窄病变的患者，已经通过血液动力学证明可以从左心室供应动脉血通过激光通道进入缺血心肌。根据对杂种狗的出色实验研究，即使在经心肌血运重建术（TMLR）的3年后，新创建的直径为0.2 mm的激光通道在组织学上也已获得专利。因此，该方法可以用作跨心肌血运重建的替代方法。单独的TMLR的第一项临床程序是对7年前进行过心包切除术的55岁重度心绞痛的男性患者进行的。他没有经皮冠状动脉介入治疗或冠状动脉搭桥术的候选人，因为他的左心室对左肺有严重的粘连。因此，该方法最终得以实施。经过外科手术后，他康复了。对于患有终末期冠状动脉疾病的患者，应建议使用此程序。

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