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首页> 外文会议>Laser resonators and beam control XIII >A self-reference sensing technique for ultra-sensitive chemical and biological detection using whispering gallery microresonators
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A self-reference sensing technique for ultra-sensitive chemical and biological detection using whispering gallery microresonators

机译：使用耳语回廊微谐振器进行超灵敏化学和生物检测的自参考传感技术

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Ultra-sensitive and label-free chemical and biological sensing devices are of great importance to biomedical research, clinical diagnostics, environmental monitoring, and homeland security applications. Optical sensors based on ultra-high-quality Whispering-Gallery-Mode (WGM) micro-resonators, in which light-matter interactions are significantly enhanced, have shown great promise in achieving compact sensors with high sensitivity and reliability. However, traditional sensing mechanisms based on monitoring the frequency shift of a single resonance faces challenges since the resonant frequency is sensitive not only to the sensing targets but also to many types of disturbances in the environment, such as temperature variation and mechanical instability of the system. The analysis of the signals is also affected by the positions of sensing targets on the resonator. Thus, it is difficult to distinguish signals coming from different sources, which introduces 'false positive' detection. We report a novel self-reference sensing mechanism based on mode splitting, a phenomenon in which a high-quality optical mode in a WGM resonator splits into two modes due to intra-cavity Rayleigh scattering. In particular, we demonstrated that the two split modes that can be induced by a single nanoparticle reside in the same resonator and serve as a reference to each other. As a result, a self-reference sensing scheme is formed. This allows us to develop a position-independent sensing scheme to accurately estimate the sizes of nanoparticles. So far we have achieved position-independent detecting and sizing of single nanoparticles down to 20 nm in radius with a single-shot measurement using an on-chip high-quality WGM microtoroid resonator.
机译：超灵敏，无标签的化学和生物传感设备对于生物医学研究，临床诊断，环境监测和国土安全应用至关重要。基于超高质量耳语画廊模式（WGM）微谐振器的光学传感器，光与物质之间的相互作用得到显着增强，在实现具有高灵敏度和可靠性的紧凑型传感器方面显示出了巨大的希望。然而，基于监视单个共振的频移的传统感测机制面临挑战，因为共振频率不仅对感测目标敏感，而且对环境中的许多类型的干扰敏感，例如温度变化和系统的机械不稳定。 。信号的分析还受到谐振器上感应目标位置的影响。因此，很难区分来自不同来源的信号，这会引入“误报”检测。我们报告了一种基于模式分裂的新型自参考传感机制，该现象是由于腔内瑞利散射导致WGM谐振器中的高质量光学模式分裂为两种模式的现象。特别地，我们证明了单个纳米粒子可以诱导的两个分裂模式驻留在同一谐振器中，并且相互充当参考。结果，形成了自参考感测方案。这使我们能够开发与位置无关的传感方案，以准确估算纳米粒子的尺寸。到目前为止，我们已经通过使用片上高质量WGM微环形谐振器进行单次测量，实现了半径不超过20 nm的单个纳米粒子的位置无关的检测和尺寸确定。

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