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首页> 外文会议>Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical >Histopathology of ultrashort pulsed laser retinal damage: changing retinal pathology with variation in spot size for near-infrared laser lesions
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Histopathology of ultrashort pulsed laser retinal damage: changing retinal pathology with variation in spot size for near-infrared laser lesions

机译：超短脉冲激光视网膜损伤的组织病理学：随着近红外激光病变的斑点大小变化而改变视网膜病理学

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Abstract: We wish to identify the change in extent of retinal tissue injury due to varying the spot size at the retina of ultrashort laser pulses. We compared the effects of delivery of near infrared (1060 nm) single laser pulses to an 800 micron diameter retinal spot to previously reported laser retinal effects. We examined macular lesions 24 hours after delivery of near-infrared (1060 nm wavelength) ultrashort laser to 804 micron spot-size, using fundus examination, fundus photographs and fluorescein angiograms. Using light microscopy, we examined sections of these lesions obtained 24 hours after laser delivery. The degree of retinal damage was compared to our data published previously by using a modified version of our previous grading scale. The 150 fs near infrared, large spot laser lesions were remarkable in their clinical and pathological appearance. The lesions, rather than centering on a single focal spot of pallor as typically seen in pulsed laser lesions of the retina, demonstrated a spotted pattern of multiple focal lesions across the area of laser delivery. There was also choroidal damage in several eyes but the Bruch's membrane remained intact. Although there was choroidal damage in the 150 fs near infrared wavelength small spot laser lesions there was not significant thermal spread. The small spot ultrashort visible wavelength showed no significant thermal spread and no choroidal damage. Larger spot-size demonstrated a broader area of damage than that of the smaller spot-size and different choroidal effect when compared to smaller sized lesions. !18
机译：摘要：我们希望找出由于改变超短激光脉冲在视网膜上的光斑大小而引起的视网膜组织损伤程度的变化。我们比较了将近红外（1060 nm）单激光脉冲传送到直径为800微米的视网膜光斑的效果与以前报道的激光视网膜光的效果。我们通过眼底检查，眼底照片和荧光素血管造影检查近红外（1060 nm波长）超短激光至804微米斑点大小后24小时内的黄斑病变。使用光学显微镜，我们检查了激光递送后24小时获得的这些病变的切片。通过使用我们以前的分级量表的修改版本，将视网膜损伤的程度与我们先前发布的数据进行比较。 150 fs的近红外大光斑激光病灶在临床和病理学表现上都非常出色。病变不像通常在视网膜脉冲激光病变中所看到的那样集中在苍白的单个焦点上，而是在整个激光递送区域内表现出多灶性病变的斑点模式。几只眼睛也有脉络膜损害，但布鲁赫膜仍完整。尽管在150 fs的近红外波长的小斑点激光损伤中脉络膜受到损害，但没有明显的热扩散。小点的超短可见光波长没有明显的热扩散，也没有脉络膜损害。与较小的病变相比，较大的斑点表现出比较小斑点和更大的脉络膜效应更大的损伤区域。 ！18

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