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Laser mass-ablation efficiency measurements indicate bubble-driven dynamics dominate laser thrombolysis

机译:激光消融效率测量表明,气泡驱动的动力学主导着激光溶栓治疗

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Abstract: Mass removal experiments have been performed at the Oregon Medical Laser Center with 10 to 100 mJ 1 microsecond laser pulses at optical wavelengths. Above the energy threshold for bubble formation, the laser mass ablation efficiency ($mu@g/mJ) for removal of gel surrogate thrombus is nearly constant for a given experimental geometry and gel absorption coefficient. The efficiency in 'contact' experiments, in which the optical fiber delivering the energy is in close proximity to the absorbing gel, is approximately three times that of 'non-contact' experiments, in which the optical fiber is approximately 1 mm from the gel. Mass removal occurs hundreds of microseconds after the laser deposition. Experimental data and numerical simulations are consistent with the hypothesis that jet formation during bubble collapse plays a dominant role in mass removal. This hypothesis suggests a model in which the mass removed scales linearly with the maximum bubble volume and explains the distinctive features, including the magnitude, of the mass removal. !21
机译:摘要:已经在俄勒冈医疗激光中心进行了质量去除实验,使用了10至100 mJ 1微秒的激光脉冲在光波长处。在气泡形成的能量阈值以上,对于给定的实验几何形状和凝胶吸收系数,用于去除凝胶替代血栓的激光质量消融效率($ mu @ g / mJ)几乎恒定。 “接触”实验的效率大约是“非接触”实验的三倍,在“接触”实验中,传递能量的光纤非常接近吸收凝胶,在“非接触”实验中,光纤距凝胶大约1毫米。 。在激光沉积后数百微秒内发生质量去除。实验数据和数值模拟与以下假设一致:气泡破裂过程中的射流形成在质量去除中起主要作用。该假设提出了一个模型,其中去除的质量与最大气泡体积成线性比例,并解释了去除质量的独特特征(包括大小)。 !21

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