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Computer-Aided Detection of Polyps in CT Colonography with Pixel-Based Machine Learning Techniques

机译:基于像素的机器学习技术在计算机辅助结肠镜中息肉的计算机辅助检测

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Pixel/voxel-based machine-learning techniques have been developed for classification between polyp regions of interest (ROIs) and non-polyp ROIs in computer-aided detection (CADe) of polyps in CT colonography (CTC). Although 2D/3D ROIs can be high-dimensional, they may reside in a lower dimensional manifold. We investigated the manifold structure of 2D CTC ROIs by use of the Laplacian eigenmaps technique. We compared a support vector machine (SVM) classifier with the Laplacian eigenmaps-based dimensionality-reduced ROIs with massive-training support vector regression (MTSVR) in reduction of false positive (FP) detections. The Laplacian eigenmaps-based SVM classifier removed 16.0% (78/489) of FPs without any loss of polyps in a leave-one-lesion-out cross-validation test, whereas the MTSVR removed 49.9% (244/489); thus, yielded a 96.6% by-polyp sensitivity at an FP rate of 2.4 (254/106) per patient.
机译:已经开发了基于像素/体素的机器学习技术,用于在计算机结肠成像(CTC)息肉的计算机辅助检测(CADe)中对息肉感兴趣区域(ROI)和非息肉ROI之间进行分类。尽管2D / 3D ROI可以是高维的,但它们可以驻留在较低维的流形中。我们使用拉普拉斯特征图技术研究了二维CTC ROI的流形结构。我们将支持向量机(SVM)分类器与基于Laplacian特征图的降维ROI与大规模训练支持向量回归(MTSVR)进行了比较,以减少假阳性(FP)检测。基于Laplacian特征图的SVM分类器在留一病灶交叉验证测试中去除了16.0%(78/489)的FP,而息肉没有任何损失,而MTSVR去除了49.9%(244/489)。因此,每位患者的FP率为2.4(254/106),息肉敏感性为96.6%。

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