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Biocompatibility and biofunctionality of magnetic nanoparticles

机译：磁性纳米粒子的生物相容性和生物功能

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摘要

Biocompatible magnetic nanoparticles (MNPs) have been researched for bioapplications such as imaging for diagnostics, drug delivery, hyperthermia and gene delivery. In addition, MNPs are functionalized for dispersion, biocompatibility and enhancement of therapeutic effects. In this study, polyethylenimine (PEI)-coated MNPs were prepared. The localization of PEI and PEI coated MNPs in a cell was observed with phase contrast and fluorescent microscopy and transmission electron microscopy (TEM). In addition, PEI coated MNPs were conjugated with DNA for application to magnetofection. The size distribution of preinternalized DNA/PEI/MNPs complexes after applying a dc magnetic field was measured. The size of preinternalized complexes was compared to that of internalized complexes measured by TEM. Moreover, the effect of a protein corona on cellular uptake was confirmed by size measurement and transfection experiment.
机译：已经研究了生物相容性磁性纳米颗粒（MNP）的生物应用，例如用于诊断，药物输送，热疗和基因输送的成像。另外，MNP被功能化以分散，生物相容性和增强治疗效果。在这项研究中，制备了聚乙烯亚胺（PEI）涂层的MNP。用相差，荧光显微镜和透射电子显微镜（TEM）观察PEI和PEI包被的MNP在细胞中的定位。另外，将PEI包被的MNP与DNA缀合以用于磁转染。在施加直流磁场后，测量了预先内在化的DNA / PEI / MNPs复合物的大小分布。将预先内在化的配合物的尺寸与通过TEM测量的内在化的配合物的尺寸进行比较。此外，通过尺寸测量和转染实验证实了蛋白电晕对细胞摄取的影响。

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  • 会议地点 Cancun(MX)
  • 作者

    S. Ota; T. Yamada; Y. Takemura;

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    Department of Electrical and Computer Engineering, Yokohama National University, Yokohama 240-8501, Japan;

    Department of Electrical and Computer Engineering, Yokohama National University, Yokohama 240-8501, Japan;

    Department of Electrical and Computer Engineering, Yokohama National University, Yokohama 240-8501, Japan;

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