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Comparison of cellular responses induced by low level light in different cell types

机译：在不同细胞类型中弱光诱导的细胞反应的比较

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摘要

Discoveries are rapidly being made in multiple laboratories that shed "light" on the fundamental molecular and cellular mechanisms underlying the use of low level light therapy (LLLT) in vitro, in animal models and in clinical practice. Increases in cellular levels of respiration, in cytochrome c oxidase activity, in ATP levels and in cyclic AMP have been found. Increased expression of reactive oxygen species and release of nitric oxide have also been shown. In order for these molecular changes to have a major effect on cell behavior, it is likely that various transcription factors will be activated, possibly via different signal transduction pathways. In this report we compare and contrast the effects of LLLT in vitro on murine embryonic fibroblasts, primary cortical neurons, cardiomyocytes and bone-marrow derived dendritic cells. We also examined two human cell lines, HeLa cancer cells and HaCaT keratinocytes. The effects of 810-nm near-infra-red light delivered at low and high fluences were addressed. Reactive oxygen species generation, transcription factor activation and ATP increases are reported. The data has led to the hypothesis that cells with a high level of mitochondrial activity (mitochondrial membrane potential) have a higher response to light than cells with low mitochondrial activity.
机译：多个实验室正在迅速发现，这些实验室揭示了体外，动物模型和临床实践中使用低水平光疗法（LLLT）的基本分子和细胞机制。已经发现细胞呼吸水平，细胞色素c氧化酶活性，ATP水平和环状AMP的增加。还已经显示出活性氧的表达增加和一氧化氮的释放。为了使这些分子变化对细胞行为产生重大影响，可能会通过不同的信号转导途径激活各种转录因子。在本报告中，我们比较并对比了LLLT在体外对鼠类胚胎成纤维细胞，原代皮层神经元，心肌细胞和骨髓来源的树突状细胞的影响。我们还检查了两种人类细胞系，HeLa癌细胞和HaCaT角质形成细胞。解决了以低和高通量传输810 nm近红外光的影响。报告了活性氧的产生，转录因子激活和ATP增加。数据导致以下假设：线粒体活性高（线粒体膜电位）的细胞比线粒体活性低的细胞对光的响应更高。

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  • 来源
    《Mechanisms for low-light therapy V》|2010年|P.75520A.1-75520A.10|共10页
  • 会议地点 San Francisco CA(US)
  • 作者

    Ying-Ying Huang; AaronC-Hchen; SulbhaK Sharma; Qiuhe Wu; Michael Rhamblin;

  • 作者单位

    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston MA Department of Dermatology, Harvard Medical School, Boston MA Aesthetic and Plastic Center of Guangxi Medical University, Nanning, P.R China;

    rnWellman Center for Photomedicine, Massachusetts General Hospital, Boston MA Boston University School of Medicine, Graduate Medical Sciences, Boston MA;

    rnWellman Center for Photomedicine, Massachusetts General Hospital, Boston MA Department of Dermatology, Harvard Medical School, Boston MA;

    rnWellman Center for Photomedicine, Massachusetts General Hospital, Boston MA Department of Dermatology, Harvard Medical School, Boston MA Department of Burns and Plastic Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, P.R.China;

    rnWellman Center for Photomedicine, M;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医用物理学;
  • 关键词

    biostimulation; low level laser therapy; mitochondria; cytochrome c oxidase; reactive oxygen species; nuclear factor kappa B; ATP;

    机译：生物刺激低水平激光治疗；线粒体细胞色素c氧化酶；活性氧核因子κB; ATP;

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