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首页> 外文会议>Mechanisms for Low-Light Therapy; Progress in Biomedical Optics and Imaging; vol.7 no.26 >To begin at the beginning: The science of bio-stimulation in cells and tissues
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To begin at the beginning: The science of bio-stimulation in cells and tissues

机译：从头开始：在细胞和组织中进行生物刺激的科学

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There have been numerous reports describing the phenomena of low-level light therapy (LLLT) within the clinic and its broad application to alleviate pain, enhance the rate of wound healing, including spinal cord injury, reduce inflammation, improve learning, bolster immunity and combat disease. Yet, despite the breadth of potential applications for which bio-stimulation may prove beneficial, there persists a dramatic ignorance in our understanding of the signal pathways that govern these effects. At the cellular level, there exist a variety of endogenous chromophores such as cytochrome C oxidase, NADPH, FAD, FMN and other factors intrinsic to the electron transport chain in mitochondria that absorb light of specific wavelength and will undoubtedly have their role in bio-stimulation, however the dose dependency of effect with regard to total light fluence and fluence rate, as well as the importance of specific subcellular targeting, remains elusive. Furthermore, the translation of cellular response(s) in vitro to in vivo needs to be expounded. Clearly, a rigorous examination of bio-stimulatory parameters as a function of cellular and tissue response is necessary if we are to attain optimized, reproducible protocols based on a true scientific rationale for using bio-stimulation as a therapeutic modality in clinic. This paper introduces a number of the challenges we now face for advancing the bio-stimulation phenomena into the scientific mainstream by highlighting our current knowledge in this field as well as some of the research that we are conducting using LLLT in combination with photodynamic therapy.
机译：已有大量报道描述了诊所内的低水平光疗法（LLLT）现象及其在减轻疼痛，提高伤口愈合率（包括脊髓损伤），减少炎症，改善学习，增强免疫力和对抗方面的广泛应用。疾病。然而，尽管生物刺激可能被证明有益于广泛的潜在应用，但在我们对控制这些效应的信号途径的理解中仍然存在巨大的无知。在细胞水平上，线粒体中存在多种内源性生色团，例如细胞色素C氧化酶，NADPH，FAD，FMN和电子传输链固有的其他因素，它们吸收特定波长的光，无疑将在生物刺激中发挥作用但是，关于总光通量和通量率的剂量依赖性效应以及特定亚细胞靶向的重要性仍然难以捉摸。此外，需要阐明细胞应答在体外向体内的转化。显然，如果要基于在临床上使用生物刺激作为治疗手段的真实科学依据，获得优化，可重现的方案，则必须严格检查作为细胞和组织反应函数的生物刺激参数。本文通过强调我们在该领域的当前知识以及我们正在使用LLLT结合光动力疗法进行的一些研究，介绍了我们目前在将生物刺激现象推进到科学主流中所面临的许多挑战。

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