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首页> 外文会议>Mechanisms for Low-Light Therapy; Progress in Biomedical Optics and Imaging; vol.7 no.26 >Primary, secondary and tertiary effects of phototherapy: a review
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Primary, secondary and tertiary effects of phototherapy: a review

机译：光疗的主要，次要和三次作用：综述

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摘要

The classification of the cellular effects of phototherapy into primary, secondary and tertiary types is an aid to understanding variation in the predictability of the events that follow its application. Primary effects are generally restricted to the absorption of photons by cytochromes and catalytic interactions with these and other intracellular molecules. If suprathreshold, they stimulate cell activity, initiating secondary anabolic effects in those cells affected by the photons. These events can also be initiated by non-photonic stimuli. Some of the secondary effects, such as growth factor secretion, can produce effects in cells that did not absorb photons. It is proposed that this group of effects be classified as tertiary. Primary effects are strongly predictable, secondary effects less so, being dependent on cell sensitivity, while tertiary effects are the least predictable, being affected by variation in both the internal and external environment and by intercellular interactions. The investigation of primary and secondary effects of phototherapy can be used to determine which irradiation parameters are ineffective in vitro and therefore cannot be effective in vivo. Since tertiary effects predominate in vivo only clinical testing can demonstrate which parameters are most likely to be effective, and with what level of predictability. It is essential that all relevant exposure conditions be recorded and disseminated if experimental work is to be of clinical value. It is also essential that all relevant information about the target of phototherapy, be it molecule, organelle, cell, healthy volunteer or patient, be recorded and disseminated.
机译：将光疗的细胞作用分为主要，次要和第三类类型，有助于理解其应用后事件可预测性的变化。主要作用通常限于细胞色素对光子的吸收以及与这些和其他细胞内分子的催化相互作用。如果高于阈值，它们会刺激细胞活性，从而在受光子影响的那些细胞中引发次级合成代谢作用。这些事件也可以由非光子刺激引发。一些次级作用，例如生长因子的分泌，可以在不吸收光子的细胞中产生作用。建议将这组效果归为第三级。主要作用是可预测的，而次要作用则取决于细胞的敏感性，而次要作用是最不可预测的，受内部和外部环境的变化以及细胞间相互作用的影响。对光疗的主要和次要作用的研究可用于确定哪些照射参数在体外无效，因此在体内无效。由于第三效应在体内占主导地位，因此只有临床测试才能证明哪些参数最可能有效，以及可预测的水平。要使实验工作具有临床价值，必须记录并传播所有相关的接触条件。还必须记录并传播有关光疗目标的所有相关信息，无论是分子，细胞器，细胞，健康志愿者还是患者。

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