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Photosensitized inactivation of infectious agents for sterilization of red blood cell concentrates and whole blood

机译：光敏灭活传染剂，用于浓缩红细胞和全血

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Abstract: More than 10 million units of human blood components are transfused annually in the United States. Although donor screening and testing have greatly lowered the risk of transmission of viral and protozoan infectious agents, additional sterilization procedures which also preserve blood component function would be of significant value. Use of visible-light- range photosensitizers for sterilization of red blood cells is currently being aggressively investigated in laboratory-scale optical-mechanical systems. Both the photochemical sterilization process and the optical-mechanical system must operate without introducing significant alteration in the properties of the red cells. With successful demonstration of the efficacy and safety of these sterilization techniques, implementation in the blood bank setting will require scale-up to optical-mechanical systems capable of handling approximately 50,000 units daily in 500 - 1,000 blood banks in the United States.!38
机译：摘要：在美国，每年有超过1000万单位的人类血液成分被输血。尽管捐献者的筛查和测试大大降低了病毒和原生动物传染剂传播的风险，但是还可以保留血液成分功能的其他灭菌程序将具有重大价值。目前正在实验室规模的光学机械系统中积极研究使用可见光范围的光敏剂对红细胞进行灭菌。光化学灭菌过程和光学机械系统都必须在不引起红细胞特性显着改变的情况下运行。要成功证明这些灭菌技术的有效性和安全性，在血库环境中实施将需要扩大到光机械系统，该系统每天可在美国500至1,000个血库中处理约50,000个单位！38

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