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Myocardial anisotropy in genesis of abnormal Q waves in hypertrophic cardiomyopathy: a simulation study

机译:肥厚型心肌病中异常Q波发生的心肌各向异性:模拟研究

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Computer simulation with a whole-heart model was conducted to study genesis of abnormal Q waves in hypertrophic cardiomyopathy (HCM). The anatomic feature of HCM was modeled based on clinical echocardiogram images. Possible changes in anisotropy as well as in other electrophysiologic properties in hypertrophic tissue were simulated based on pathologic findings. Simulated ECGs showing the main features of HCM were obtained by assuming isotropic fiber orientation in hypertrophic tissue and by changing other properties from normal values. This study suggests a possible mechanism to account for abnormal Q waves in HCM.
机译:用全心模型进行计算机模拟以研究肥厚型心肌病(HCM)中异常Q波的发生。基于临床超声心动图图像对HCM的解剖特征进行建模。基于病理学发现,对肥厚组织中各向异性以及其他电生理特性的可能变化进行了模拟。通过假设肥大组织中各向同性的纤维取向以及通过将其他特性从正常值更改来获得显示HCM主要特征的模拟ECG。这项研究提出了一种可能的机制来解释HCM中的异常Q波。

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