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The leading edge is the primary force producing component of migrating fibroblasts

机译：前缘是成纤维细胞迁移的主要力量产生因素

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To examine how cells generate force at the level of single extracellular matrix fibers, a miniature force-transducer system was created around a novel microfabricated silicon device. We characterize the development of isometric force on single collagen type-I fibers. We show that cells remodel individual collagen fibers by moving them inward using a hand-over-hand cycle of binding, movement, and release. This remodelling is caused by only a 2-3 micrometer region of active lamellapodium. We also show that movement of individual fibers is rapid at low restrictive forces, and this velocity quickly decreases as forces approach 60 pN. A single cell is capable of generating between 180-250 pN of force on a single fiber. This data supports the hypothesis that the leading edge of migrating cells is primarily responsible for generating force on the substrate.
机译：为了检查细胞如何在单个细胞外基质纤维水平上产生力，围绕新型微加工硅器件创建了一个微型力传感器系统。我们表征了单一I型胶原纤维上等距力的发展。我们显示细胞通过使用结合，移动和释放的移交周期向内移动它们来重塑单个胶原纤维。这种重塑仅由活性鳞茎的2-3微米区域引起。我们还表明，在限制力较小的情况下，单个纤维的运动迅速，并且当力接近60 pN时，该速度迅速降低。单个单元格能够在单个光纤上产生180-250 pN的力。该数据支持以下假设：迁移细胞的前缘主要负责在底物上产生力。

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