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Overview of functional infrared imaging as part of a multi-imaging strategy for breast cancer detection and therapeutic monitoring

机译：功能红外成像概述作为乳腺癌检测和治疗监测多成像策略的一部分

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To assess infrared imaging as a first line detection strategy, we retrospectively reviewed the relative ability of our preoperative clinical exam, mammography, and infrared imaging to detect 100 new cases of ductal carcinoma in situ, Stage I and II breast cancer. While the false-negative rate of infrared imaging was 17%, at least one abnormal infrared sign was detected in the remaining 83 cases, including 10 of the 15 patients, a slightly younger cohort, who had nonspecific mammograms. The 85% sensitivity rate of mammography alone thus increased to 95% when combining both imaging modalities. Access to infrared information was also pertinent when confronted with the relatively frequent contributory but equivocal clinical exam (34%) and mammography (19%). The average size of those tumors undetected by mammography or infrared imaging was 1.66 cm and 1.28 cm, respectively, while the false-positive rate of infrared imaging in a concurrent series of 100 successive benign open breast biopsies was 19%. Our initial experience would suggest that, when done concomitantly with clinical exam and mammography, high-resolution digital infrared imaging can provide additional safe, practical, first-line and objective information. To assess infrared imaging as a therapeutic monitoring tool, 20 successive patients who received preoperative chemohormonotherapy (PCT) for locally advanced breast cancer underwent high resolution digital infrared imaging (IR) both before and after PTC and prior to surgery. The images were graded using a new scale. Initial pre-PCT IR imaging revealed obvious and often dramatic angiogenesis-related findings in all our patients. Following PCT, there was a significant decrease in both the IR score and in the clinical size of those with measurable disease. Four of the six patients with complete pathological response also saw their IR revert to normal. In nine patients, the elevated pre-PCT IR score lingered longer than the clinical findings. IR provides a very safe and convenient alternative functional imaging modality to monitor PCT. Further study and follow-up is required to assess whether the IR changes that reflect the effect of PCT on tumor vascularity also provide an additional valuable prognostic indicator for this subset of patients with aggressive tumors.
机译：为了评估红外成像作为一线检测策略，我们回顾性地回顾了术前临床检查，乳房X线照片和红外成像检测100例原位导管癌，I期和II期乳腺癌新病例的相对能力。红外成像的假阴性率为17％，在其余83例患者中至少检测到一个异常的红外体征，包括15例年龄较小的队列中的10例，他们的乳房X线照片没有特异性。因此，当结合两种成像方式时，仅乳房X线照片的85％敏感度就提高到了95％。当面对相对频繁的，但模棱两可的临床检查（34％）和乳腺摄影（19％）时，获得红外信息也很重要。乳房X线摄影或红外成像未检出的那些肿瘤的平均大小分别为1.66 cm和1.28 cm，而同时进行的100例连续良性开放性乳腺活检中，红外成像的假阳性率为19％。我们的初步经验表明，与临床检查和乳房X线照相术同时进行时，高分辨率数字红外成像可以提供额外的安全，实用，第一线和客观的信息。为了评估红外成像作为一种治疗监测工具，连续20例接受局部局部乳腺癌的术前化学激素疗法（PCT）的患者在PTC前后，术前均接受了高分辨率数字红外成像（IR）。使用新的比例尺对图像进行分级。最初的PCT前IR成像揭示了我们所有患者中明显且通常是剧烈的与血管生成相关的发现。 PCT之后，患有可测量疾病的患者的IR评分和临床规模均显着下降。六个完全病理反应的患者中有四个也看到其IR恢复正常。在9例患者中，PCT前IR评分升高的持续时间长于临床结果。 IR提供了一种非常安全和方便的替代功能成像方式来监视PCT。需要进一步的研究和随访，以评估反映PCT对肿瘤血管作用的IR变化是否也为侵袭性肿瘤患者的这一亚组提供了额外的有价值的预后指标。

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