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ARMEDA II: supporting genomic medicine through the integration of medical and genetic databases

机译：ARMEDA II：通过整合医学和遗传数据库来支持基因组医学

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In this paper we present ARMEDA II, a project designed to integrate distributed heterogeneous medical and genetic databases in support of genomic medicine. In this project, we have followed a "virtual repository" or VR approach. Although VRs are entities that do not contain any data, but metadata, they give users the perception of being working with local repositories that integrate data from different and remote sources. Our approach is based on two basic operators employed to connect new databases to the system: mapping and unification. The mapping process produces what is called the "virtual conceptual schema" of the newly created VR while the unification process provides tools to create an integrated virtual schema for at least two pre-existing VRs. We tested the current implementation of ARMEDA Il using two tumor databases, one containing information from a hospital and the other containing genetic data associated to the tumor samples. The performance of the system was also evaluated using a pre-created set of 30 queries. For all queries the test yielded promising results since the system successfully retrieved the correct information. The ARMEDA II project is the current version of an ongoing project developed in the framework of an European Commission funded project.
机译：在本文中，我们介绍了ARMEDA II，这是一个旨在集成分布式异构医学和遗传数据库以支持基因组医学的项目。在此项目中，我们遵循了“虚拟存储库”或VR方法。尽管VR是不包含任何数据但包含元数据的实体，但它们给用户以正在使用集成了来自不同远程资源的数据的本地存储库的感觉。我们的方法基于用于将新数据库连接到系统的两个基本运算符：映射和统一。映射过程产生了新创建的VR的所谓的“虚拟概念架构”，而统一过程则提供了为至少两个预先存在的VR创建集成的虚拟架构的工具。我们使用两个肿瘤数据库测试了ARMEDA II的当前实施方式，一个数据库包含来自医院的信息，另一个数据库包含与肿瘤样品相关的遗传数据。还使用预先创建的30个查询集评估了系统的性能。对于所有查询，由于系统成功检索了正确的信息，因此测试产生了可喜的结果。 ARMEDA II项目是在欧盟委员会资助的项目框架内开发的正在进行中项目的最新版本。

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