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The Role of Opioid in the Mechanism of the Hypotensive Effect by Simulating Acupuncture on Rat Hindlimb

机译：阿片类药物通过模拟针刺对大鼠后肢的降压作用机制中的作用

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The present study investigated the role of central opioid in the hypotensive effect of somatic afferent inputs. The femoral arterial pressure and electrocardiogram (ECG) of rats were recorded when the hypothalamic paraventricular nucleus (the PVN) was electrically stimulated or chemically activated (microinjection of L-glutamate) with or without microinjection of naloxone into the lateral ventricle of brain. Stimulation of the deep peroneal nerve (the DPN) decreased the pressor response elicited by electrical stimulation or chemical activation of the PVN. This inhibitory effect was reduced by microinjection of naloxone into the lateral ventricle of brain. These data suggest that opioid receptor in brain is involved in the inhibitory effect of stimulating the DPN on the pressor response induced by activation of the PVN
机译：本研究调查了中央阿片样物质在体细胞传入输入的降压作用中的作用。当对下丘脑室旁核（PVN）进行电刺激或化学激活（L-谷氨酸的微注射），或不向脑侧脑室微注射纳洛酮时，记录大鼠的股动脉压和心电图（ECG）。腓总神经（DPN）的刺激降低了电刺激或PVN的化学活化引起的升压反应。通过将纳洛酮微注射到脑侧脑室可以降低这种抑制作用。这些数据表明，大脑中的阿片样物质受体参与了刺激DPN对PVN激活所引起的升压反应的抑制作用。

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