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Combining Comparative Genomics with de novo Motif Discovery to Identify Human Transcription Factor DNA-Binding Motifs

机译：将比较基因组学与从头发现相结合，以鉴定人类转录因子DNA结合基序。

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As more and more genomes are sequenced, comparative genomics approaches provide a methodology for identifying conserved regulatory elements that may be involved in gene regulation. In this study, we combined comparative genomics with de novo motif discovery to identify potential human transcription factor binding motifs that are overrepresented and conserved in the upstream regions of a set of co-regulated genes. We validated our approach by analyzing a well-characterized muscle specific gene set. Our approach also performed better than other existing programs, such as Toucan and CompareProspector, based on the motif discovery results for the muscle data set.

机译：随着测序越来越多的基因组，比较基因组学方法提供了一种用于鉴定可能参与基因调节的保守调节元件的方法。在这项研究中，我们将比较基因组合与De Novo Motif发现组合，以鉴定潜在的人转录因子结合基序，其在一组共调基因的上游区域中持久化并保守。我们通过分析一种表征良好的肌肉特异性基因集来验证了我们的方法。我们的方法也比其他现有程序更好地执行，例如Toucan和CompareProspector，基于肌肉数据集的图案发现结果。

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《》|2006年|P.158-163|共6页
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Linyong Mao; Zheng; W.J.;
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1. Combining comparative genomics with de novo motif discovery to identify human transcription factor DNA-binding motifs [J] . Linyong Mao, W Jim Zheng BMC Bioinformatics . 2006,第SUPPLEMENTa4期

机译：将比较基因组学与De Novo Motif发现结合鉴定人转录因子DNA结合基序
2. A novel motif-discovery algorithm to identify co-regulatory motifs in large transcription factor and microRNA co-regulatory networks in human [J] . Liang Cheng, Li Yue, Luo Jiawei, Bioinformatics . 2015,第14期

机译：一种新颖的基序发现算法，可识别人类大转录因子和microRNA共同调控网络中的共同调控主题
3. A novel motif-discovery algorithm to identify co-regulatory motifs in large transcription factor and microRNA co-regulatory networks in human [J] . Liang Cheng, Li Yue, Luo Jiawei, Bioinformatics . 2015,第14期

机译：一种新颖的基序发现算法，可识别人类大转录因子和microRNA共同调控网络中的共同调控主题
4. Combining Comparative Genomics with de novo Motif Discovery to Identify Human Transcription Factor DNA-Binding Motifs [C] . Linyong Mao, W. Jim Zheng International Multi-Symposiums on Computer and Computational Sciences . 2006

机译：将比较基因组学与De Novo Motif发现结合鉴定人转录因子DNA结合基序
5. Computational studies of de novo motif discovery in aptamer selections. [D] . Shieh, Kevin R. 2016

机译：适体选择中从头发现基序的计算研究。
6. Combining comparative genomics with de novo motif discovery to identify human transcription factor DNA-binding motifs [O] . Linyong Mao, W Jim Zheng 2006

机译：将比较基因组学与从头发现基元相结合以鉴定人类转录因子DNA结合基序
7. Combining comparative genomics with de novo motif discovery to identify human transcription factor DNA-binding motifs [O] . Mao, Linyong, Zheng, W Jim 2006

机译：将比较基因组学与de novo基序发现相结合，以鉴定人类转录因子DNA结合基序

Combining Comparative Genomics with de novo Motif Discovery to Identify Human Transcription Factor DNA-Binding Motifs

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