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Myocardial perfusion evaluation with T2-prepared gradient echo blood oxygen level dependent imaging at 3 Tesla

机译:T2梯度回波血氧水平依赖性成像在3 Tesla时的心肌灌注评估

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Detecting myocardial perfusion reserve differences using blood oxygen level dependent (BOLD) MRI may improve at 3 T vs 1.5 T. Stenosis-model dogs (n=3) were imaged at 3 T using a gradient echo sequence (GRE) with T2-preparation for BOLD weighting and without as a control. 3 short-axis slices were acquired at rest and during stenosis and adenosine-induced stress with fluorescent microspheres injected to provide blood flow information. Quantitative measurements showed significant changes for BOLD images (left anterior descending (LAD) or septal vs left circumflex (LCX) regions=1.20/spl plusmn/0.11; LAD vs septal regions=1.03/spl plusmn/0.06; p>0.001), but not for control images (LAD or septal vs LCX regions=1.01/spl plusmn/0.04; LAD vs septal regions=0.99/spl plusmn/0.05; p=0.09). BOLD MR vs microsphere measured flow (MR=0.053*SPHERE+1.03) showed good correlation (R=0.61). In conclusion, 3 T BOLD imaging was able to identify myocardial perfusion changes.
机译:使用血氧水平依赖性(BOLD)MRI检测心肌灌注储备差异可能在3 T和1.5 T时有所改善。使用T2制备的梯度回波序列(GRE)在3 T对狭窄模型犬(n = 3)成像。粗体加权,不作为控制。在静止,狭窄和腺苷诱导的压力下,通过注射荧光微球获得3个短轴切片,以提供血流信息。定量测量显示BOLD图像有显着变化(左前降(LAD)或中隔与左旋支(LCX)区域= 1.20 / spl plusmn / 0.11; LAD相对于中隔区域= 1.03 / spl plusmn / 0.06; p> 0.001),但是不适用于对照图片(LAD或间隔vs LCX区域= 1.01 / spl plusmn / 0.04; LAD相对于间隔区域= 0.99 / spl plusmn / 0.05; p = 0.09)。粗体MR与微球测得的流量(MR = 0.053 * SPHERE + 1.03)显示出良好的相关性(R = 0.61)。总之,3 T BOLD成像能够识别心肌灌注变化。

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