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Effects of mechanical stress and scaffold material on osteogenesis and chondrogenesis

机译：机械应力和支架材料对成骨和软骨形成的影响

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The present study was designed to investigate how mouse bone marrow stromal ST2 cells and rat limb mesenchymal stem cells respond to mechanical stress. Mechanical stress loading culture devices originally developed or commercially available were used to induce quantitative strain to these cells. Differentiation of ST2, estimated by alkaline phosphatase (ALP), was shown to be affected by the amount of the strain. Chondrogenic cell differentiation was enhanced by stretch stimulation through phosphplylation of extracellular-signaling regulated kinases (ERKs). In this study, the effect of synthetic scaffold octacalcium phosphate (OCP) was also determined. OCP implantation enhanced bone regeneration. The results suggest that the differentiation of these skeletal tissue forming cells is under control of the mechanical stresses through the signaling cascade. It is likely that the scaffold plays a role of site scaffolding the cells to assist differentiation.
机译：本研究旨在研究小鼠骨髓基质ST2细胞和大鼠肢体间充质干细胞对机械应激的反应。最初开发的或可商购的机械应力负荷培养装置用于诱导对这些细胞的定量应变。由碱性磷酸酶（ALP）估计的ST2的分化显示受菌株数量的影响。通过胞外信号调节激酶（ERK）的磷酸化进行拉伸刺激，可增强软骨细胞的分化。在这项研究中，还确定了合成支架八磷酸钙（OCP）的作用。 OCP植入可增强骨骼再生。结果表明，这些骨骼组织形成细胞的分化处于通过信号级联的机械应力的控制之下。支架可能在位点支架细胞中起到辅助分化的作用。

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