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首页> 外文会议>International symposium on halogenated persistent organic pollutants >TIME TRENDS OF PERSISTENT CHEMICALS IN HUMANS – QUANTIFIYING EXPOSURE TRENDS AND ELIMINATION HALF-LIVES FROM POPULATION BIOMONITORING DATA
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TIME TRENDS OF PERSISTENT CHEMICALS IN HUMANS – QUANTIFIYING EXPOSURE TRENDS AND ELIMINATION HALF-LIVES FROM POPULATION BIOMONITORING DATA

机译：人类持久化学品的持久化学品时间趋势 - 来自人口生物监测数据的消除半衰期

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摘要

Population time trends of persistent chemicals are assembled by building time series of different sets of crosssectional monitoring data (CSD). We refer to such time trends as cross sectional trend data (CSTD). We developed a multi-individual pharmacokinetic framework that quantifies the influence of the exposure trend (i.e. long-term change in daily intake) and the elimination half-life (i.e. the clearance from the human body). Under post-ban conditions (i.e. if only individuals having spent their lifetime in a post-ban phase are included in CSTD), the framework provides analytically explicit pharmacokinetic equations describing CSD and CSTD. It is current practice to use log-linear regression to quantify declining trends observed in CSTD. However, results from log-linear regressions have been interpreted in various, sometimes inconsistent ways. Here, we employ a multi-individual pharmacokinetic framework to (i) show that exponential fits of CSTD are a direct quantitative measure of exposure and independent from elimination kinetics if all individuals included in the trend study have spent their lifetime under post ban conditions, and (ii) to establish a method to estimate human elimination half-lives for persistent chemicals under background exposure conditions that uses CSTD instead of sequential measurements in individuals.
机译：通过建立不同的横截面监测数据（CSD）的时间序列组装持久化学品的人口时间趋势。我们将这种时间趋势称为横截面趋势数据（CSTD）。我们开发了一种多单独的药代动力学框架，这些框架量化了暴露趋势的影响（即每日摄入量的长期变化）和消除半衰期（即人体的间隙）。在禁止后条件下（即只有在CSTD中包含在禁止淘汰阶段的个人在CSTD中包含），该框架提供了描述CSD和CSTD的分析性显式药代动力学方程。目前使用Log-Linear回归是使用Log-Linear回归来量化CSTD中观察到的下降趋势。但是，Log-Linear回归的结果已被解释为各种，有时是不一致的方式。在这里，我们使用多个人的药代动力学框架至（i）表明CSTD的指数配合是暴露的直接定量测量，并且如果趋势研究中包含的所有个人在禁止条件下的寿命中都花了它们的所有职能，并且（ii）建立一种在使用CSTD的背景暴露条件下为持久化学品估算人类消除半衰期的方法，而不是个人中的顺序测量。

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