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首页> 外文会议>World congress on medical physics and biomedical engineering;International congress of the IUPESM >The 21st Birthday Party for intensity-modulated radiation therapy (IMRT); 21 years from 1988-2009; From concept to practical reality
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The 21st Birthday Party for intensity-modulated radiation therapy (IMRT); 21 years from 1988-2009; From concept to practical reality

机译：强度调制放射治疗（IMRT）的21岁生日聚会; 1988-2009年的21年;从概念到实际

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IMRT is now a major clinical specialty. It is a form of conformal radiation therapy which is specifically tailored to create a high-dose volume that matches the volumetric shape of the intended target region and simultaneously spares the nearby organs at risk. It is particularly competent for treating head-and-neck cancers, prostate, lung, breast and other targets where adjacent organs at risk are present. The development of IMRT is firmly rooted in physics and specifically the branch of physics known as medical physics. IMRT was "born" in about 1988 in that this was the year in which the pioneering paper on inverse planning for IMRT of Anders Brahme appeared. In the years immediately following, a small handful of workers, including the author, developed methods to plan and deliver IMRT. By the mid 1990s the main methods were established using phantom materials in University Hospitals. Clinical IMRT started in 1994 and, for a few years thereafter, commenced in a very limited number of specialist institutions. By the turn of the millennium the technique was beginning to be established more widely and in 2009 it is regarded as a clinical necessity for many tumour sites and has Worldwide popularity. This lecture will review this growth and present the main IMRT planning and delivery landmarks along the developmental path. The clinical rationale will be explained. Some pre-history will also be discussed. The technologies of multiple-static multileaf collimator IMRT, dynamic MLC IMRT, Tomotherapy, robotic IMRT, volume modulated arc therapy will be explained. Specific early planning systems will be mentioned. The role of the author's Centre in establishing clinical IMRT in the UK will be explained. Finally, as IMRT becomes a regularly used tool, attention will switch to combining 3D and 4D medical imaging with IMRT, so called IGRT, for taking care of organ motion.
机译：IMRT现在是主要的临床专业。它是保形放射疗法的一种形式，专门用于产生高剂量体积，该体积与预期目标区域的体积形状相匹配，同时避免了附近有风险的器官。它特别适合治疗头颈癌，前列腺癌，肺癌，乳腺癌和其他存在危险器官的靶标。 IMRT的发展牢固地植根于物理学，特别是物理学的一个分支，即医学物理学。 IMRT大约在1988年“诞生”，这一年出现了关于安德斯·布拉姆（Anders Brahme）的IMRT逆向计划的开创性论文。在随后的几年中，包括作者在内的少数工人开发了计划和实施IMRT的方法。到1990年代中期，主要方法已在大学医院中使用幻像材料建立。 IMRT临床始于1994年，此后的几年中，在非常有限的专业机构中开始进行。到千年之交，该技术开始得到更广泛的应用，2009年，它被认为是许多肿瘤部位的临床必需品，并且在世界范围内得到普及。本讲座将回顾这一增长，并介绍IMRT在发展道路上的主要规划和交付标志。将说明临床原理。还将讨论一些史前史。将解释多静态多叶准直仪IMRT，动态MLC IMRT，Tomotherapy，机器人IMRT，体积调制电弧疗法的技术。具体的早期计划系统将被提及。将解释作者中心在英国建立临床IMRT的作用。最终，随着IMRT成为常用工具，人们将注意力转向将3D和4D医学成像与IMRT（即所谓的IGRT）结合起来，以照顾器官运动。

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