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首页> 外文会议>World congress on medical physics and biomedical engineering;International congress of the IUPESM >Brain White Matter Pathological Comparison in MS Relapsing-Remitting Patients, Clinically Isolated Syndrome Patients and Normal Subjects Using Quantitative Magnetization Transfer Imaging
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Brain White Matter Pathological Comparison in MS Relapsing-Remitting Patients, Clinically Isolated Syndrome Patients and Normal Subjects Using Quantitative Magnetization Transfer Imaging

机译：使用定量磁化转移成像技术的MS复发型患者，临床孤立综合征患者和正常受试者的脑白质病理学比较

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The aim of this study is to investigate abnormali-ties and characterize pathologic changes associated with demy-elination in the brain tissue of patients with multiple sclerosis (MS). In this method, magnetization transfer parameters such as magnetization transfer ratio (MTR), magnetization transfer rate (K_sat) and native relaxation time of brain tissue with and without saturating pulse were determined (Tlfree , T1_sat). Measurements were performed with both of segmentation regional measurements. It had been shown that individual valuables contributing to magnetization transfer process can be provide further insight into the mechanisms of myelin de-struction in multiple sclerosis disease.Conventional MR imaging protocols such as Tl-weighted, T2-weighted, T2-FLAIR as well as MT-3DSPGR images were performed on ten MS patients and ten normal subjects.White matter and lesion masks were segmented from T2-weighted images and superimposed on MT parameter maps using FSL software. MTI parameters of lesions and normal appearing white matter (NAWM) were analyzed in compari-son with those of normal volunteers.Group mean Tl relaxation times throughout NAWM in-creased when going from control subjects to CIS to RR MS. In the RR and CIS MS groups, the Tl increases compared with control subjects were significant throughout the NAWM, without apparent preference for specific brain regions.Significant reduction in NAWM-MTI parameters of MS pa-tients compared to normal subjects shows that pathological changes occur outside visible lesions on conventional MR im-ages among patients with multiple sclerosis. Quantitative MT imaging can help to evaluate the extent of global damage in the brain tissue.The results showed that at a group level there is widespread involvement of WM throughout the brain in CIS MS and especially in RRMS, where a significant Tl increase was found in 15.58% of WM voxels (Normal < RR).
机译：这项研究的目的是调查多发性硬化症（MS）患者脑组织中与脱髓鞘相关的异常并描述病理变化。在此方法中，确定了带有和不带有饱和脉冲的脑组织的磁化传递参数，例如磁化传递比（MTR），磁化传递速率（K_sat）和自然松弛时间（Tlfree，T1_sat）。进行了两个区域分割测量。已经表明，有助于磁化转移过程的各个贵重物品可以进一步了解多发性硬化症中髓鞘破坏的机理。 在10名MS患者和10名正常受试者上进行了常规MR成像方案，如T1加权，T2加权，T2-FLAIR以及MT-3DSPGR图像。 从T2加权图像中分割出白质和病变蒙版，并使用FSL软件将其叠加在MT参数图上。与正常志愿者比较，分析了病变和正常出现的白质（NAWM）的MTI参数。 从对照组到CIS到RR MS，整个NAWM的组平均T1松弛时间增加。在RR和CIS MS组中，在整个NAWM中，与对照受试者相比，T1增加是显着的，而对特定脑区域没有明显的偏好。 与正常受试者相比，MS患者的NAWM-MTI参数显着降低表明，在多发性硬化症患者中，常规MR图像上可见病变之外发生了病理变化。 MT定量成像可以帮助评估脑组织中整体损伤的程度。 结果表明，在群体水平上，WM在CIS MS中尤其是RRMS中遍及整个大脑，其中W1体素中15.5％的T1显着增加（正常

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