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首页> 外文会议>Conference on physiology and function from multidimensional images >Quantification of tumor microvascular permeability in human glioma xenografts using dynamic T1 MRI with Gadomer-17
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Quantification of tumor microvascular permeability in human glioma xenografts using dynamic T1 MRI with Gadomer-17

机译：用Gadomer-17使用动态T1 MRI的人胶质瘤异种移植物中肿瘤微血管渗透性的定量

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摘要

Dynamic Magnetic Resonance Imaging (T$-1$/-mapping) using the Gadolinium complex Gadomer-17, was applied to characterize the vascular permeability of human glioma xenografts implanted in nude mice. We aimed at measuring permeability differences in two types of glioma xenograft lines with a known difference in perfusion status. The T$-1$/-data could be analyzed according to the Tofts-Kermode compartmental model for modeling tracer kinetics to vascular permeability. This vascular permeability was mapped as the permeability surface area product per unit of leakage volume (k). The two tumor types displayed different k-maps. For the fast growing E102 tumor, we observed a homogeneous distribution of the vascular permeability across the tumor with a mean k-value of (0.207 plus or minus 0.027) min$+$MIN@1$/. However, for the slowly growing E106 tumor, we could distinguish four different regions with different permeability characteristics: a well-perfused rim $LB@k equals (0.30 plus or minus 0.09) min$+$MIN@1$/$RB@, regions at the inner side of the tumor with lower permeability $LB@k equals (0.130 plus or minus 0.019) min$+$MIN@1$/$RB@, regions at the inner side of the tumor around necrotic regions demonstrating locally increased permeability $LB@k equals (0.33 plus or minus 0.11) min$+$MIN@1$/$RB@, and necrotic regions.
机译：使用钆复合聚合物-17的动态磁共振成像（T-$ / - 映射）应用于植入裸鼠中的人胶质瘤异种移植物的血管渗透性。我们旨在测量两种类型的胶质瘤异种移植线的渗透性差异，具有已知灌注状态的已知差异。可以根据Tofts-Kermode分区模型进行分析T $ -1 $ / - 数据，用于将示踪动力学建模到血管渗透性。将该血管渗透性映射为每单位泄漏体积（k）的渗透性表面积产品。两个肿瘤类型显示出不同的k型映射。对于快速生长的E102肿瘤，我们观察到在肿瘤上的血管渗透性均匀分布，平均值（0.207加或减去0.027）MIN $ + $ MIN @ 1 $ /。然而，对于慢慢生长的E106肿瘤，我们可以将四个不同的区域区分开不同的渗透性特征：一个良好的灌注RIM $ LB @ K等于（0.30加号0.09）最低$ + $ MIN @ 1 $ / $ RB @，肿瘤内侧的地区具有较低的渗透率$ lb @ k等于（0.130加号或0.019）分钟$ + $ min @ 1 $ / $ rb @，肿瘤内侧的地区围绕坏死地区展示局部增加渗透率$ lb @ k等于（0.33加号或0.11）min $ + $ min @ 1 $ / $ rb @和坏死地区。

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