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首页> 外文会议>Conference on physiology and function from multidimensional images >Accurate estimation of contrast agent dynamics in fast contrast-enhanced MRI
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Accurate estimation of contrast agent dynamics in fast contrast-enhanced MRI

机译：在快速增强MRI中精确估计造影剂动态

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Contrast enhanced MRI (CE-MRI) is increasingly being used for tumor characterization as well as therapy response monitoring. We are investigating the diagnostic value of fast, multi-slice $LB@1.5$MUL@1.5$MUL@5(mm)$RB CE-MRI with a time interval of 2(s) to enables estimating perfusion parameters. A clinical visualization tool is being developed that estimates curve parameters on a per voxel basis to be able to analyze the heterogeneous tumor physiology. MRI image noise strongly affects the (perfusion) related start-of-enhancement and time- to-peak estimates especially in low contrast curves. We therefore developed a robust estimation method. It was tested on realistic simulations and in vivo CE-MRI data and compared to existing methods. The new method is shown to be more accurate, precise and robust than common least-squares optimization based methods.
机译：对比增强MRI（CE-MRI）越来越多地用于肿瘤表征以及治疗反应监测。我们正在调查快速，多切片$ LB @ 1.5 $ MUL @ 1.5 $ MUL @ 5（mm）$ RB CE-MRI的诊断价值，其中2（s）的时间间隔来实现估算灌注参数。正在开发临床可视化工具，其估计每个体素的曲线参数，以便能够分析异质肿瘤生理学。 MRI图像噪声强烈影响（灌注）相关的增强开始和时间到峰值估计，特别是在低对比度曲线中。因此，我们开发了一种稳健的估计方法。它对现实模拟和体内CE-MRI数据进行了测试，与现有方法进行了测试。该方法显示比公共最小二乘优化的方法更准确，精确和鲁棒。

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