Assessment of the pulse flow propagation based upon digital coronary angiograms

机译：基于数字冠状动脉血管造影的脉冲流量传播评估

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Our purpose is to assess the pulse flow propagation from series of digital coronary angiograms. The local dilation- contraction pattern along the vessel is a measure for the elasticity and endothelian function. A small distensibility could be an indication for the presence of atherosclerosis also in cases where the angiogram is not abnormal. We have developed an analytical model of the pulse flow propagation in coronary arteries. In the model the artery is a straight elastic tube and is not moving due to the motion of the heart. The pulsatile flow of contrast agent is modeled for clinically relevant parameters and predictions of coronary angiograms are obtained for various characteristics of elasticity such as modulus, compliance and ratio. In the clinical angiograms, we compute the local vessel diameter from frame to frame. Because of the heart motion it is not so easy to track the vessel diameter on the same spot. Motion estimation and compensation are required. Algorithms for these processing steps are implemented. We have obtained satisfactory model simulations and predictions of angiograms. The simulated-dilation- contraction patterns help to understand the more complicated clinical angiograms. We have obtained various pulse flow patterns from coronary angiograms of a small patient population.

机译：我们的目的是评估来自一系列数字冠状动脉血管造影的脉冲流量传播。沿着容器的局部扩张图案是弹性和内皮功能的衡量标准。在血管造影不是异常的情况下，在血管造影的情况下也可能是动脉粥样硬化存在的表现。我们已经开发了冠状动脉脉冲流量传播的分析模型。在模型中，动脉是直的弹性管，并且由于心脏的运动而不是移动。造影剂的脉动流量被建模用于临床相关参数，并且可以获得冠状动脉血管造影的预测，用于各种弹性特性，例如模量，顺应性和比例。在临床血管造影中，我们将局部容器直径从框架计算到框架。由于心动运动，追踪同一点的血管直径并不容易。需要运动估计和补偿。实现了这些处理步骤的算法。我们已经获得了令人满意的模型模拟和对血管造影的预测。模拟膨胀 - 收缩模式有助于理解更复杂的临床血管仪。我们已经获得了来自小患者群体的冠状动脉血管造影的各种脉搏流动模式。

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《Conference on physiology and function from multidimensional images》|2000年||共10页
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Cornelis H. Slump; Marc Schrijver; Henny Kuipers; Corstiaan J. Storm;
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Assessment of the pulse flow propagation based upon digital coronary angiograms

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