PREPARATION OF A RAPIDLY DISINTEGRATING TABLET IN THE ORAL CAVITY BY DIRECT COMPRESSION METHOD

机译：直接压片法制备口腔快速崩解片

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In this study microcrystalline cellulose and low-substituted hydroxy-propylcellulose were used as binder-disintegrants, ethenzamide and ascorbic acid, as poor water soluble and water soluble model drugs respectively, to make a rapidly disintegrating tablet by direct compression method. This study was conducted to find a new improved method to facilitate the oral administration of drugs to the elderly. The disintegration and wetting mechanisms of this tablet were discussed and a disintegration method different than the one discribed in JPXXII was presented.

机译：在这项研究中，微晶纤维素和低取代羟丙基纤维素分别用作粘合剂-崩解剂，乙酰胺和抗坏血酸，分别作为水溶性差和水溶性的模型药物，通过直接压片法制成快速崩解的片剂。进行这项研究以发现一种新的改进方法，以促进老年人口服药物。讨论了该片剂的崩解和润湿机理，并提出了不同于JPXXII中描述的崩解方法。

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《Proceedings '96 China-Japan symjposium on particuology》|1996年|P.68|共1页
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Yunxia Bi; Hisakazu Sunada;
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正文语种
中图分类粉末技术;
关键词
microcrystalline cellulose; low-substituted hydroxypropylcellulose; wetting; swell; porosity; disintegration; oral cavity;

机译：微晶纤维素;低取代羟丙基纤维素;润湿;溶胀;孔隙度;崩解;口腔;

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专利

1. Preparation of rapidly disintegrating tablet using new types of microcrystalline cellulose (PH-M series) and low substituted-hydroxypropylcellulose or spherical sugar granules by direct compression method. [J] . Ishikawa T, Mukai B, Shiraishi S, Chemical and Pharmaceutical Bulletin . 2001,第2期

机译：用新型微晶纤维素（PH-M系列）和低取代羟丙基纤维素或球形糖颗粒通过直接压片法制备速崩片。
2. Preparation of orally disintegrating tablets from active ingredients of citrus peel by direct powder compression for the maintenance of brain function [J] . Nakamura Shohei, Abe Sae, Miyoshi Kazuki, Food science and technology research . 2021,第4期

机译：通过直接粉末压缩从柑橘果皮的活性成分进行口服崩解片剂，以维持脑功能
3. Preparation and evaluation of furosemide containing orally disintegrating tablets by direct compression [J] . Gulsun T., Ozturk N., Kaynak M. S., Die Pharmazie . 2017,第7期

机译：通过直接压缩制备呋塞米含有口服崩解片剂的评价
4. PREPARATION OF A RAPIDLY DISINTEGRATING TABLET IN THE ORAL CAVITY BY DIRECT COMPRESSION METHOD [C] . Yunxia Bi, Hisakazu Sunada Proceedings '96 China-Japan symjposium on particuology . 1996

机译：直接压片法制备口腔快速崩解片
5. Amorphous to crystalline transformation in maltose: Implications for orally disintegrating tablets. [D] . Hostetler, Scott Eric. 2002

机译：麦芽糖中的无定形至结晶转化：对口腔崩解片的影响。
6. Orally-disintegrating Tablets in Fixed-dose Combination Containing Ambroxol Hydrochloride and Salbutamol Sulphate Prepared by Direct Compression: Formulation Design Development and In Vitro Evaluation [O] . Deepak SHARMA, Rajindra SINGH, Gurmeet SINGH 2018

机译：直接压制的盐酸氨溴索和硫酸沙丁胺醇固定剂量组合的口腔崩解片：制剂设计开发和体外评价
7. Preparation of Rapidly Disintegrating Tablet Using New Types of Microcrystalline Cellulose (PH-M Series) and Low Substituted-Hydroxypropylcellulose or Spherical Sugar Granules by Direct Compression Method. [O] . Tatsuya ISHIKAWA, Baku MUKAI, Shuji SHIRAISHI, 2001

机译：用直接压缩法制备新型微晶纤维素（pH-M系列）和低取代 - 羟丙基纤维素或球形糖颗粒的快速崩解片。

PREPARATION OF A RAPIDLY DISINTEGRATING TABLET IN THE ORAL CAVITY BY DIRECT COMPRESSION METHOD

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