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Expression of thyroid hormone receptor-alpha in the growth and development of the sea bream (sparus aurata)

机译:甲状腺激素受体-α在鲷鱼(金头鲷)的生长和发育中的表达

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Thyroid hormones (THs) play a number of roles in vertebrate organisms. In mammals, in addition to influencing basic metabolic rate, THs affect prenatal and post-natal development, with transgenic mice lacking the thyroid hormone receptor (TR)-alpha dying within a few weeks of birth, apparently due to an inability to complete some of the maturation processes required for survival in the post-weaning period (Fraichard et al., 1997). Additionally, TH deficiency during differentiation causes a number of abnormalities including neurological and skeletal defects.
机译:甲状腺激素(THs)在脊椎动物中起着许多作用。在哺乳动物中,THs除了影响基本代谢率外,还影响产前和产后发育,转基因小鼠在出生后数周内缺乏甲状腺激素受体(TR)-α的死亡,这显然是由于无法完成其中的一部分。断奶后存活所需的成熟过程(Fraichard等,1997)。另外,在分化过程中TH缺乏会引起许多异常,包括神经和骨骼缺陷。

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