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首页> 外文会议>AIChE annual meeting >NOVEL BIOMIMETIC POLYMER NETWORKS: DEVELOPMENT AND APPLICATION AS SELECTIVE RECOGNITION ELEMENTS FOR BIOMOLECULES AT THE MICRO-/NANO-SCALE
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NOVEL BIOMIMETIC POLYMER NETWORKS: DEVELOPMENT AND APPLICATION AS SELECTIVE RECOGNITION ELEMENTS FOR BIOMOLECULES AT THE MICRO-/NANO-SCALE

机译：新型生物聚合物网络：作为微/纳米尺度生物分子的选择性识别元素的开发和应用

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Novel biomimetic polymer networks were developed that are entirely synthetic and tailored to have various properties and function. These artificial networks have numerous applications such as sensing elements in biosensors, intelligent drug delivery devices, and immunoassays. In comparison to biological entities, biomimetic polymer networks are advantageous because they can be designed to mimic biological recognition pathways and at the same time exhibit other abiotic properties that are more favorable, such as greater stability in harsh environments. For many applications, it is necessary to integrate these polymeric networks at the micro-ano-scale. In our laboratory, procedures have been developed to facilitate this micro-ano-scale application. A mask aligner was utilized to enable precise micropatterning of ultra-thin polymers films via UV freeradical polymerization. For the case where these organic polymer networks were patterned onto inorganic silicon substrates, an organosilane coupling agent was utilized to gain covalent adhesion between the dissimilar polymer network and the silicon surface. As an example application, a glucose microsensor was developed based on a patterned biomimetic polymer network designed to selectively recognize D-glucose among similar molecules via non-covalent complexation. Novel copolymer networks containing poly(ethylene glycol) dimethacrylate and functional monomers such as acrylic acid, methacrylic acid, and acrylamide were synthesized in polar, aprotic solvent (dimethyl sulfoxide). Results qualitatively and quantitatively demonstrate that these recognitive macromolecular networks are specific for the target molecule and can be effectively micropatterned in fine dimensions. These results are encouraging for the further development of functionalized micro-biosensors and diagnostic devices and are applicable to other biologically significant molecules and biomimetic polymer networks, in which hydrogen bonding, hydrophobic, or ionic contributions will direct recognition.
机译：已开发出完全合成的新型仿生聚合物网络，这些网络经过定制以具有各种特性和功能。这些人工网络具有许多应用，例如生物传感器中的传感元件，智能药物输送设备和免疫测定。与生物实体相比，仿生聚合物网络是有利的，因为可以将它们设计为模仿生物识别途径，同时展现出更有利的其他非生物特性，例如在恶劣环境中的更高稳定性。对于许多应用，有必要在微米/纳米级集成这些聚合物网络。在我们的实验室中，已经开发了一些程序来促进这种微米/纳米规模的应用。利用掩模对准器，可以通过紫外线自由基聚合对超薄聚合物薄膜进行精确的微图案化。对于将这些有机聚合物网络图案化到无机硅衬底上的情况，使用有机硅烷偶联剂来获得异种聚合物网络和硅表面之间的共价粘合。作为示例应用，基于图案化的仿生聚合物网络开发了一种葡萄糖微传感器，该仿生聚合物网络旨在通过非共价络合选择性地识别相似分子之间的D-葡萄糖。在极性非质子传递溶剂（二甲基亚砜）中合成了包含聚乙二醇二甲基丙烯酸酯和丙烯酸，甲基丙烯酸和丙烯酰胺等功能性单体的新型共聚物网络。定性和定量结果表明，这些识别性大分子网络对目标分子具有特异性，并且可以有效地在精细尺寸上进行微图案化。这些结果对于功能化微型生物传感器和诊断设备的进一步发展是令人鼓舞的，并且可应用于其他具有生物学意义的分子和仿生聚合物网络，其中氢键，疏水或离子作用将直接识别。

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