EFFICIENT IN VIVO GENE DELIVERY BY THE COMPLEX OF CATIONIC EMULSION AND PLASMID DNA

机译：阳离子乳状液和质粒DNA的复合体可高效递送体内基因

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In this study, cationic emulsions were prepared with varying composition of 3β[N-(N',N'-dimethylaminoethane)carbamoyl]-cholesterol (DC-Choi), dioleoylphosphatidylethanolamine (DOPE), caster oil and Tween 80 and their transfection efficiency was evaluated in vivo. Compared to cationic liposomes, cationic emulsions were more stable in biological condition and showed longer gene expression in various tissues.

机译：在这项研究中，制备了具有不同组成的3β[N-（N'，N'-二甲基氨基乙烷）氨基甲酰基]-胆固醇（DC-Choi），二油酰基磷脂酰乙醇胺（DOPE），蓖麻油和Tween 80组成的阳离子乳液，其转染效率为体内评估。与阳离子脂质体相比，阳离子乳液在生物学条件下更稳定，并在各种组织中显示更长的基因表达。

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来源
《Proceedings of the 29th Annual Meeting of the Controlled Release Society》|2002年|p.1363-1364|共2页
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W.-J. Choi; S.-H. Choi; W.-S. Ahn; C.-.K. Kim;
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正文语种
中图分类化学工业;
关键词
emulsions; transfection;

机译：乳液;转染;

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专利

1. Efficient in vivo gene delivery by the negatively charged complexes of cationic liposomes and plasmid DNA [J] . Kyonghee K. Son, Diane Tkach, Kevin J. Hall Biochimica et biophysica acta. Biomembranes . 2000,第1a2期

机译：阳离子脂质体和质粒DNA带负电荷的复合物可有效进行体内基因传递
2. Stabilization of cationic liposome‐plasmid DNA complexes by polyamines and poly(ethylene glycol)‐phospholipid conjugates for efficient in vivo gene delivery [J] . Baker Andrew, Hong Keelung, Papahadjopoulos Demetrios, FEBS Letters . 1997,第2期

机译：多胺和聚（乙二醇）-磷脂缀合物稳定阳离子脂质体-质粒DNA复合物以有效地体内基因传递
3. Gene expression in an intact ex-vivo skin tissue model following percutaneous delivery of cationic liposome-plasmid DNA complexes. [J] . Birchall JC, Marichal C, Campbell L, International Journal of Pharmaceutics . 2000,第1a2期

机译：经皮递送阳离子脂质体-质粒DNA复合物后，完整的离体皮肤组织模型中的基因表达。
4. EFFICIENT IN VIVO GENE DELIVERY BY THE COMPLEX OF CATIONIC EMULSION AND PLASMID DNA [C] . W.-J. Choi, S.-H. Choi, W.-S. Ahn, Annual meeting of the Controlled Release Society . 2002

机译：通过阳离子乳液和质粒DNA的复合物递增体内基因递送
5. Polyionic complexes from cationic block copolymers and plasmid DNA for gene delivery [D] . Lai, Tsz Chung 2012

机译：来自阳离子嵌段共聚物和质粒DNA的聚离子复合物，用于基因传递
6. From gene delivery to gene silencing: plasmid DNA-transfecting cationic lipid 13-dimyristoylamidopropane-2-bis-(2-dimethylaminoethane) carbamate efficiently promotes small interfering RNA-induced RNA interference [O] . Michael Spelios, Molinda Kearns, Michalakis Savva -1

机译：从基因递送到基因沉默：质粒DNa转染阳离子脂质13- dimyristoylamidopropane -2- 双 - （2-二甲基氨基乙烷）氨基甲酸酯有效地促进小干扰RNa诱导的RNa干扰
7. Efficient in vivo gene delivery by the negatively charged complexes of cationic liposomes and plasmid DNA [O] . Son Kyonghee K, Tkach Diane, Hall Kevin J 2000

机译：阳离子脂质体和质粒DNA带负电荷的复合物可有效进行体内基因传递

EFFICIENT IN VIVO GENE DELIVERY BY THE COMPLEX OF CATIONIC EMULSION AND PLASMID DNA

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