ENHANCED INTESTINAL ABSORPTION OF LHRH AND LEUPROLIDE IN THE RAT FROM LIPID POLYMER MICELLES

机译：脂质聚合物胶束增强大鼠肠道LHRH和亮丙肽的吸收

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The intestinal absorption of LHRH and leuprolide was determined in rats from various lipid polymer micelle formulations. Upon intraduodenal administration of LHRH or leuprolide consistent and reproducible pharmacokinetics was obtained with a mean relative bioavailability of about 10 and 28%, respectively. There was a dose dependence of LHRH and leuprolide absorption.

机译：从各种脂质聚合物胶束制剂的大鼠中测定了LHRH和亮丙瑞林的肠吸收。在十二指肠内施用LHRH或亮丙瑞林后，可获得一致且可重现的药代动力学，其平均相对生物利用度分别约为10％和28％。 LHRH和亮丙瑞林吸收存在剂量依赖性。

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《Proceedings of the 29th Annual Meeting of the Controlled Release Society》|2002年|p.976-977|共2页
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P. P. Constantinides; L. Liang; E.-H. Jang; D. Fast; L. He; L. Li; K. Bosnian; K. Opeifa;
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中图分类化学工业;
关键词
LHRH; polymeric micelles; drug absorption;

机译：LHRH;聚合物胶束;药物吸收;

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4. ENHANCED INTESTINAL ABSORPTION OF LHRH AND LEUPROLIDE IN THE RAT FROM LIPID POLYMER MICELLES [C] . P. P. Constantinides, L. Liang, E.-H. Jang, Annual meeting of the Controlled Release Society . 2002

机译：从脂质聚合物胶束的大鼠中增强LHRH和Leuplolide的肠道吸收
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ENHANCED INTESTINAL ABSORPTION OF LHRH AND LEUPROLIDE IN THE RAT FROM LIPID POLYMER MICELLES

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