EXTENSIVE TISSUE DISTRIBUTION OF AMPHOTERICIN B AFTER INTRAVENOUS ADMINISTRATION IN COCHLEATE VEHICLE TO MICE

机译：小鼠静脉给药后两性霉素B的广泛组织分布。

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AMB-cochleate formulation given IV to mice showed a two-phase pharmacokinetic profile. Pharmacokinetic analysis in target tissues (liver, spleen, kidney and lungs) shows a multi-peak profile, large AUC and MRT. Extensive tissue distribution, consistent with the role of macrophages clearing particulates, makes AMB-cochleates apt to treat "deep mycoses".

机译：静脉给予小鼠的AMB-耳蜗制剂显示出两相药代动力学曲线。在靶组织（肝，脾，肾和肺）中的药代动力学分析显示多峰分布，较大的AUC和MRT。广泛的组织分布与巨噬细胞清除颗粒的作用一致，使AMB耳蜗易于治疗“深部真菌病”。

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《Proceedings of the 29th Annual Meeting of the Controlled Release Society》|2002年|p.734-735|共2页
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I. Segarra; D. A. Movshin; L. Zarif;
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中图分类化学工业;
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drug delivery; cochleates; antifungal agents;

机译：药物输送;耳蜗类;抗真菌药;

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专利

1. Pharmacokinetics and tissue distribution after intravenous administration of a single dose of amphotericin B cochleates, a new lipid-based delivery system. [J] . Segarra I, Movshin DA, Zarif L Journal of pharmaceutical sciences. . 2002,第8期

机译：静脉给药单剂量两性霉素B耳蜗蛋白后，其药物代谢动力学和组织分布是一种新的基于脂质的递送系统。
2. Heat treatment of amphotericin b modifies its serum pharmacokinetics, tissue distribution, and renal toxicity following administration of a single intravenous dose to rabbits. [J] . Kwong EH, Ramaswamy M, Bauer EA, Antimicrobial agents and chemotherapy. . 2001,第7期

机译：在给兔子单次静脉注射剂量后，两性霉素b的热处理会改变其血清药代动力学，组织分布和肾毒性。
3. Pharmacokinetic evaluation of amphotericin B in lung tissue: lung lymph distribution after intravenous injection and airspace distribution after aerosolization and inhalation of amphotericin B. [J] . Koizumi T, Kubo K, Kaneki T, Antimicrobial agents and chemotherapy. . 1998,第7期

机译：两性霉素B在肺组织中的药代动力学评估：静脉注射后的肺淋巴分布以及两性霉素B雾化和吸入后的空域分布。
4. EXTENSIVE TISSUE DISTRIBUTION OF AMPHOTERICIN B AFTER INTRAVENOUS ADMINISTRATION IN COCHLEATE VEHICLE TO MICE [C] . I. Segarra, D. A. Movshin, L. Zarif Annual meeting of the Controlled Release Society . 2002

机译：静脉内施用后静脉内施用后的两性霉素B的大规模组织分布到小鼠
5. Intravenous self-administration of alcohol in selectively bred high- and low-alcohol preferring mice [D] . Green, Alexis Suzanne 2011

机译：选择性饲养高，低酒精偏爱小鼠的酒精静脉自我给药
6. Heat Treatment of Amphotericin B Modifies Its Serum Pharmacokinetics Tissue Distribution and Renal Toxicity following Administration of a Single Intravenous Dose to Rabbits [O] . Evan H. Kwong, Manisha Ramaswamy, Emily A. Bauer, 2001

机译：对兔子进行单一静脉给药后两性霉素B的热处理会改变其血清药代动力学组织分布和肾脏毒性。
7. Heat Treatment of Amphotericin B Modifies Its Serum Pharmacokinetics, Tissue Distribution, and Renal Toxicity following Administration of a Single Intravenous Dose to Rabbits [O] . Kwong, Evan H., Ramaswamy, Manisha, Bauer, Emily A., 2001

机译：对兔子进行单一静脉给药后，两性霉素B的热处理会改变其血清药代动力学，组织分布和肾脏毒性。
8. Toxic Effects of the Intravenous Administration of Camptothecin NA Salt (Nsc-100 880) IN Dogs and Monkeys. Toxic Effects of the Intravenous and Oral Administration in Mice [R] . Schaeppi, U., Rosenkrantz, H., Mason, M. M., 1968

机译：静脉注射喜树碱Na盐（Nsc-100 880）对犬和猴的毒性作用。静脉和口服给药对小鼠的毒性作用

EXTENSIVE TISSUE DISTRIBUTION OF AMPHOTERICIN B AFTER INTRAVENOUS ADMINISTRATION IN COCHLEATE VEHICLE TO MICE

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