HPMA COPOLYMERS WITH HYDRAZONE-ATTACHED DOXORUBICIN ARE EFFICIENT IN THE TREATMENT OF MOUSE T CELL LYMPHOMA EL4

机译：含羟基的阿霉素的HPMA共聚物可有效治疗小鼠T细胞淋巴瘤EL4

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

The aim of the present work was to compare the in vivo effect of poly(HPMA) conjugates with hydrazone-attached doxorubicin on blood clearance and growth of mouse cancer EL4. The conjugates were synthesized with two different side chains (GG, GFLG), with lower (M_w～20 kDa) and higher (M_w～110 kDa) molecular weight, with or without targeted structure. We have concluded that hydrazone conjugates remained in blood circulation longer than free drug and had better therapeutic effect on mouse T cell lymphoma EL4 than free drug or PK1 conjugate.

机译：本工作的目的是比较聚（HPMA）偶联物与连接的阿霉素对小鼠癌EL4的血液清除和生长的体内作用。合成的结合物具有两条不同的侧链（GG，GFLG），分子量较低（M_w〜20 kDa），分子量较高（M_w〜110 kDa），具有或不具有目标结构。我们得出的结论是，缀合物在血液循环中的停留时间比游离药物更长，并且比游离药物或PK1缀合物对小鼠T细胞淋巴瘤EL4的治疗效果更好。

著录项

来源
《Proceedings of the 29th Annual Meeting of the Controlled Release Society》|2002年|p.1215-1216|共2页
会议地点
作者
M. Jelinkova; M. Sirova; K. Ulbrich; J. Strohalm; M. Pechar; T. Etrych; B. Rihova;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类化学工业;
关键词
HPMA copolymers; tumor drug delivery; anticancer agents;

机译：HPMA共聚物;肿瘤药物递送;抗癌药;

相似文献

外文文献
中文文献
专利

1. Synergistic effect of EMFBEMER-type pulsed weak electromagnetic field and HPMA-bound doxorubicin on mouse EL4 T-cell lymphoma [J] . ?hovB., EtrychT., RovM., Journal of drug targeting . 2011,第10期

机译：EMFBEMER型脉冲弱电磁场和HPMA结合的阿霉素对小鼠EL4 T细胞淋巴瘤的协同作用
2. Doxorubicin attached to HPMA copolymer via amide bond modifies the glycosylation pattern of EL4 cells [J] . Lubomir Kovar, Tomas Etrych, Martina Kabesova, Tumor Biology . 2010,第4期

机译：通过酰胺键连接到HPMA共聚物的阿霉素修饰EL4细胞的糖基化模式
3. Doxorubicin attached to HPMA copolymer via amide bond modifies the glycosylation pattern of EL4 cells. [J] . Kovar L, Etrych T, Kabesova M, Tumour biology : . 2010,第4期

机译：通过酰胺键连接至HPMA共聚物的阿霉素可修饰EL4细胞的糖基化模式。
4. HPMA COPOLYMERS WITH HYDRAZONE-ATTACHED DOXORUBICIN ARE EFFICIENT IN THE TREATMENT OF MOUSE T CELL LYMPHOMA EL4 [C] . M. Jelinkova, M. Sirova, K. Ulbrich, Annual meeting of the Controlled Release Society . 2002

机译：HPMA共聚物与腙附着的多柔比星是有效的小鼠T细胞淋巴瘤EL4的治疗方法
5. Colon-targeted delivery of 9-aminocamptothecin by HPMA copolymer conjugates for the treatment of colon cancer. [D] . Gao, Songqi. 2009

机译：HPMA共聚物偶联物靶向结肠靶向递送9-氨基喜树碱，用于治疗结肠癌。
6. Liberation of Doxorubicin from HPMA Copolymer Conjugate is Essential for the Induction of Cell Cycle Arrest and Nuclear Fragmentation in Ovarian Carcinoma Cells [O] . A. Malugin, P. Kopečková, J. Kopeček -1

机译：从HPMA共聚物缀合物中释放阿霉素对于诱导卵巢癌细胞中的细胞周期阻滞和核分裂至关重要
7. Pegylated liposomal doxorubicin: an efficient treatment in patients with Hodgkin lymphoma relapsing after high dose therapy and stem cell transplation [O] . Thomas Clozel, Benedicte Deau, Claire Benet, 2013

机译：聚乙二醇化脂质体多柔比星：高剂量治疗和干细胞移植后霍奇金淋巴瘤患者的有效治疗

HPMA COPOLYMERS WITH HYDRAZONE-ATTACHED DOXORUBICIN ARE EFFICIENT IN THE TREATMENT OF MOUSE T CELL LYMPHOMA EL4

摘要

著录项

相似文献

相关主题

期刊订阅