IN VITRO PERCUTANEOUS ABSORPTION OF MEFENAMIC ACID ENHANCED BY COMPLEXATION WITH ALKANOLAMINES

机译：链烷醇配合物增强的海藻酸的体外透皮吸收

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Preparation of mefenemic acid (MA) - alkanolamine complex was attempted to increase the transdermal flux of MA. IR and DSC study demonstrated that the crystal of MA and amine mixture was ion-pair complex. The series of amine complex showed lower melting point, higher solubility in water and ethanol and higher transdermal flux more than MA. The flux of complex from ethanol-isopropyl myristate (EI) system through hairless rat skin might be explained by cotransport of ethanol.

机译：尝试制备甲氧苯甲酸（MA）-链烷醇胺复合物以增加MA的透皮通量。 IR和DSC研究表明MA和胺混合物的晶体是离子对络合物。该系列胺配合物比MA具有更低的熔点，更高的水和乙醇溶解度以及更高的透皮通量。乙醇-肉豆蔻酸异丙酯（EI）系统通过无毛大鼠皮肤的复合物通量可能是由乙醇的共转运所解释的。

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《Proceedings of the 29th Annual Meeting of the Controlled Release Society》|2002年|p.740-741|共2页
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L. Fang; S. Numajiri; D. Kobayashi; Y. Morimoto;
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中图分类化学工业;
关键词
mefenamic acid; complexation; transdermal delivery;

机译：甲芬那酸;络合物;透皮给药;

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1. The use of complexation with alkanolamines to facilitate skin permeation of mefenamic acid. [J] . Fang L, Numajiri S, Kobayashi D, International Journal of Pharmaceutics . 2003,第1a2期

机译：与链烷醇胺络合的使用可促进苯甲酸的皮肤渗透。
2. Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines. [J] . Fang L, Numajiri S, Kobayashi D, Journal of pharmaceutical sciences. . 2004,第1期

机译：甲芬那酸与链烷醇胺的配合物的理化和晶体学表征。
3. Penetration Enhancing Effect of Polysorbate 20 and 80 on the In Vitro Percutaneous Absorption of L-Ascorbic Acid [J] . Akhtar N, Rehman MU, Khan HMS, Tropical Journal of Pharmaceutical Research . 2011,第3期

机译：聚山梨酯20和80对L-抗坏血酸体外经皮吸收的渗透增强作用
4. IN VITRO PERCUTANEOUS ABSORPTION OF MEFENAMIC ACID ENHANCED BY COMPLEXATION WITH ALKANOLAMINES [C] . L. Fang, S. Numajiri, D. Kobayashi, Annual meeting of the Controlled Release Society . 2002

机译：通过络合与链烷醇胺络合增强梅青酸的体外经皮吸收
5. Mefenamic acid – HPMC AS HG Amorphous Solid Dispersions: Dissolution Enhancement Using Hot Melt Extrusion Technology [D] . Shukla, Ashay 2019

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8. In Vitro Percutaneous Absorption of 14C-Decamethylcyclopenta Siloxane (D5) in Rat Skin: Amendment to Report No. 1996-I0000-41226, with Cover Letter dated 12/01/1997 [R] . 1997

机译：14C-十甲基环戊硅氧烷（D5）在大鼠皮肤中的体外经皮吸收：报告编号1996-I0000-41226的修正案，附有日期为12/01/1997的求职信

IN VITRO PERCUTANEOUS ABSORPTION OF MEFENAMIC ACID ENHANCED BY COMPLEXATION WITH ALKANOLAMINES

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