SELF-ASSEMBLING INSULIN-POLYMER COMPLEXES FOR PERORAL DELIVERY: INTERACTION WITH CACO-2 CELL MONOLAYERS, PEPTIDE TRANSPORT AND CYTOTOXICITY

机译：自组装胰岛素-聚合物复合物经口给药：与CACO-2细胞单分子膜相互作用，肽转运和细胞毒性

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Peroral drug delivery systems for insulin based on the electrostatic formation of nanocomplexes between a novel class of positively charged comb-like polyesters and negatively charged insulin were investigated with regard to cytotoxicity, peptide uptake and transport through Caco-2 cell monolayers.

机译：基于细胞毒性，肽摄取和通过Caco-2细胞单层运输的新型一类带正电的梳状聚酯和带负电的胰岛素之间的纳米复合物的静电形成，针对胰岛素的经口药物递送系统进行了研究。

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来源
《Proceedings of the 29th Annual Meeting of the Controlled Release Society》|2002年|p.881-882|共2页
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Isabel Behrens; Michael Simon; Matthias Wittmar; Thomas Kissel;
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正文语种
中图分类化学工业;
关键词
CACO-2 cells; insulin; self-assembly; oral drug delivery; polyesters;

机译：CACO-2细胞;胰岛素;自组装;口服药物传递;聚酯;

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3. Transport of Free and Peptide-Bound Glycated Amino Acids: Synthesis, Transepithelial Flux at Caco-2 Cell Monolayers, and Interaction with Apical Membrane Transport Proteins [J] . Hellwig M., Geissler S., Matthes R., Chembiochem: A European journal of chemical biology . 2011,第8期

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4. SELF-ASSEMBLING INSULIN-POLYMER COMPLEXES FOR PERORAL DELIVERY: INTERACTION WITH CACO-2 CELL MONOLAYERS, PEPTIDE TRANSPORT AND CYTOTOXICITY [C] . Isabel Behrens, Michael Simon, Matthias Wittmar, Annual meeting of the Controlled Release Society . 2002

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SELF-ASSEMBLING INSULIN-POLYMER COMPLEXES FOR PERORAL DELIVERY: INTERACTION WITH CACO-2 CELL MONOLAYERS, PEPTIDE TRANSPORT AND CYTOTOXICITY

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