Effect of PEG-linker Chain Length of Folate-linked Microemulsions LoadingAclacinomycin A on Targeting Ability and Antitumor Effect in vitro and in vivo

机译：叶酸连接微乳中载有阿克拉霉素A的PEG-连接剂链长对体内外靶向能力和抗肿瘤作用的影响

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To establish a novel formulation tumor-targeteddrug carrier of lipophilic antitumor antibiotics,aclacinomycin A (ACM), folate-linkedmicroemulsions were prepared and investigatedboth in vitro and in vivo. These findings suggestthat a folate-linked microemulsion is feasible fortumor-targeted.

机译：建立针对肿瘤的新型制剂亲脂性抗肿瘤抗生素的药物载体，叶酸连接的阿克拉霉素A（ACM）微乳液的制备和研究无论是体内还是体外。这些发现表明叶酸连接的微乳液对肿瘤靶向。

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来源
《Annual meeting exposition of the Controlled Release Society》|2005年|1-2|共2页
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作者
Y. Maitani; T. Shiokawa; Y. Hattori; K. Kawano; Y. Ouguchi; H. Kawakami; K. Toma;
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正文语种
中图分类药学;
关键词
drug targeting; folate receptor; chemotherapy;

机译：靶向药物;叶酸受体; 化学疗法;

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机译：饱和脂肪酸链长对布洛芬微乳剂透皮行为影响的体外，离体和体内评估
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机译：体外，离体，以及体内评价饱和脂肪酸链长度对布洛芬的微乳液的透皮行为的影响
3. Stealth PEG-PHDCA niosomes: effects of chain length of PEG and particle size on niosomes surface properties, in vitro drug release, phagocytic uptake, in vivo pharmacokinetics and antitumor activity. [J] . Shi B, Fang C, Pei Y Journal of pharmaceutical sciences. . 2006,第9期

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4. PREPARATION AND ANTITUMOR EFFECTS OF TRYPSIN-MODIFIED PEGLATED MICROEMULSIONS AS CARRIERS OF SUICIDE GENE CONTROLLED BY TUMOR-TARGETING PROMOTER [C] . Yoshie Maitani, Wang Junping, Tsuneji Nagai, Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

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5. Antitumor studies of a traditional Hawaiian medicinal plant, Morinda citrifolia (noni), in vitro and in vivo. [D] . Hirazumi, Anne Yukiko. 1997

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Effect of PEG-linker Chain Length of Folate-linked Microemulsions LoadingAclacinomycin A on Targeting Ability and Antitumor Effect in vitro and in vivo

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