Investigating the Cytotoxicity and Mechanism of Action of Dextrin-Phospholipase A_2 Conjugates as Novel Anti-Tumour Agents

机译：研究糊精-磷脂酶A_2偶联物作为新型抗肿瘤药的细胞毒性和作用机理

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Dextrin-phospholipase A_2 (PLA_2) conjugates have been previously described [1]. They were synthesised with the aim of reducing clinical toxicity associated with PLA_2 and improving tumour targeting. The aim of this study was to investigate in vitro the mechanism of action of dextrin-PLA_2. Cytotoxicity was assessed using cells expressing different levels of epidermal growth factor receptor (EGFr) and cellular uptake by MCF7 cells was assessed.

机译：先前已经描述了糊精-磷脂酶A_2（PLA_2）缀合物[1]。合成它们的目的是减少与PLA_2相关的临床毒性并改善肿瘤靶向性。这项研究的目的是在体外研究糊精-PLA_2的作用机理。使用表达不同水平的表皮生长因子受体（EGFr）的细胞评估细胞毒性，并评估MCF7细胞对细胞的摄取。

著录项

来源
《Controlled Release Society Annual Meeting and Exposition》|2007年|P.180-181|共2页
会议地点
作者
Elaine L. Ferguson; Ruth Duncan;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类生物工程学（生物技术）;
关键词
anticancer agents; conjugates; enzyme delivery; phospholipase;

机译：抗癌剂;缀合物;酶传递;磷脂酶;

相似文献

外文文献
中文文献
专利

1. The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I. Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro [J] . F Searle, C Bier, R G Buckley, British Journal of Cancer . 1986,第3期

机译：羧肽酶G2抗体偶联物作为抗肿瘤剂的潜力。一，抗人绒毛膜促性腺激素-羧肽酶G2的制备及其结合物对JAR绒毛膜癌细胞的体外细胞毒性
2. Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management. [J] . Gardam MA, Keystone EC, Menzies R, The Lancet infectious diseases . 2003,第3期

机译：抗肿瘤坏死因子药物和结核病风险：作用机理和临床管理。
3. Arsenic trioxide as an anti-tumour agent: mechanisms of action and strategies of sensitization [J] . Yolanda Sanchez, Donna Amran, Elena de Blas, Journal of Applied Biomedicine . 2010,第4期

机译：三氧化二砷作为抗肿瘤剂：作用机理和致敏策略
4. Investigating the Cytotoxicity and Mechanism of Action of Dextrin-Phospholipase A_2 Conjugates as Novel Anti-Tumour Agents [C] . Elaine L. Ferguson, Ruth Duncan Controlled Release Society Annual Meeting and Exposition . 2007

机译：调查糊精 - 磷脂脂酶A_2缀合物作为新型抗肿瘤剂的特征和机制
5. Part I. Investigations of DNA damage mechanisms of azinomycin analogs and the natural product leinamycin. Part II. Biologically relevant chemical reactions of 1,2-dithiole-3-thiones as cancer preventive agents. [D] . Zang, Hong. 2001

机译：第一部分：阿奇霉素类似物和天然产物莱那霉素的DNA损伤机理研究。第二部分1,2-二硫代-3-硫酮作为癌症预防剂的生物学相关化学反应。
6. The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I. Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro. [O] . F. Searle, C. Bier, R. G. Buckley, 1986

机译：羧肽酶G2抗体偶联物作为抗肿瘤剂的潜力。 I.抗人绒毛膜促性腺激素-羧肽酶G2的制备以及该缀合物对JAR绒毛膜癌细胞的体外细胞毒性。
7. The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I. Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro. [O] . Searle, F., Bier, C., Buckley, R. G., 1986

机译：羧肽酶G2抗体偶联物作为抗肿瘤剂的潜力。 I.抗人绒毛膜促性腺激素-羧肽酶G2的制备以及该缀合物对JAR绒毛膜癌细胞的体外细胞毒性。

Investigating the Cytotoxicity and Mechanism of Action of Dextrin-Phospholipase A_2 Conjugates as Novel Anti-Tumour Agents

摘要

著录项

相似文献

相关主题

期刊订阅