PAMAM Dendrimers: Surface Modification and Potential in Oral Delivery of SN-38

机译：Pamam Dendrimers：SN-38口服递送的表面改性和潜力

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Poly amido amine (PAMAM) dendrimers are promising candidates for oral drug delivery due to their well-defined compact structure, versatility of surface functionalities, low polydispersity and the ability to enhance transepithelial transport. Here we report that surface acetylation of PAMAM dendrimers maintains their permeability across caco-2 cell monolayers while reducing cytotoxicity. We also report the potential of PAMAM dendrimers for oral delivery of SN-38, an active metabolite of camptothecin analogs.

机译：聚酰胺胺（PAMAM）树枝状大分子是由于其定义良好的紧凑结构，表面官能团，低多分散性和增强Transepearial运输能力的含量，用于口服药物递送的候选者。在这里，我们认为PAMAM树枝状大分子的表面乙酰化在降低细胞毒性的同时将它们的渗透性保持在Caco-2细胞单层的渗透性。我们还报告了PAMAM树枝状大分子的潜力，用于口服递送SN-38，一种活跃的Camptothecin类似物。

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《Controlled Release Society Annual Meeting and Exposition》|2007年||共2页
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Rohit B. Kolhatkar; H. Ghandehari;
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中图分类生物工程学（生物技术）;
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1. Direct Electrochemistry and Electrocatalysis of Hemoglobin at PAMAM Dendrimer-MWNTs-Au Nanoparticles Composite Film Modified Glassy Carbon Electrode [J] . LIU Xing-mei, ZHANG Xue-yu, ZHAO Yi-li, 高等学校化学研究：英文版 . 2010,第005期
2. Direct Electrochemistry and Electrocatalysis of Hemoglobin at PAMAM Dendrimer-MWNTs-Au Nanoparticles Composite Film Modified Glassy Carbon Electrode [J] . LIU Xing-mei, ZHANG Xue-yu, ZHAO Yi-li, 高等学校化学研究（英文版） . 2010,第005期
3. Potential Oral Delivery of 7-Ethyl-10-Hydroxy-Camptothecin (SN-38) using Poly(amidoamine) Dendrimers [J] . Rohit B. Kolhatkar, Peter Swaan, Hamidreza Ghandehari Pharmaceutical Research . 2008,第7期

机译：使用聚（酰胺基胺）树状聚合物的7-乙基-10-羟基喜树碱（SN-38）的潜在口服给药
4. Potential oral delivery of 7-ethyl-10-hydroxy-camptothecin (SN-38) using poly(amidoamine) dendrimers. [J] . Kolhatkar RB, Swaan P, Ghandehari H Pharmaceutical research . 2008,第7期

机译：使用聚（酰胺胺）树枝状体潜力口服递送7-乙基-10-羟基 - 喜树碱（SN-38）。
5. Anionic PAMAM dendrimers rapidly cross adult rat intestine in vitro: a potential oral delivery system? [J] . Wiwattanapatapee R, Carreno-Gomez B, Malik N, Pharmaceutical research . 2000,第8期

机译：阴离子PAMAM树状大分子在体外迅速穿过成年大鼠肠道：潜在的口服给药系统？
6. PAMAM Dendrimers: Surface Modification and Potential in Oral Delivery of SN-38 [C] . Rohit B. Kolhatkar, H. Ghandehari Controlled Release Society Annual Meeting and Exposition . 2007

机译：PAMAM树状聚合物：SN-38的表面修饰和口服传递的潜力。
7. Engineering tumor-targeted poly(amidoamine) (PAMAM) dendrimers for improved penetration and cellular delivery of short-interfering RNA (siRNA) through solid tumors [D] . Waite, Carolyn Leigh 2011

机译：工程化靶向肿瘤的聚（酰胺基胺）（PAMAM）树状大分子，以提高短干扰RNA（siRNA）通过实体瘤的渗透和细胞递送
8. Potential Oral Delivery of 7-Ethyl-10-Hydroxy-Camptothecin (SN-38) using Poly (amidoamine) Dendrimers [O] . Rohit B. Kolhatkar, Peter Swaan, Hamidreza Ghandehari -1

机译：使用聚（氨基胺）树状聚合物的7-乙基-10-羟基喜树碱（SN-38）的潜在口服给药
9. Transepithelial transport and toxicity of PAMAM dendrimers: Implications for oral drug delivery [O] . S. Sadekar, H. Ghandehari 2012

机译：PAMAM Dendrimers的Transepithelial运输和毒性：对口服药物交付的影响

PAMAM Dendrimers: Surface Modification and Potential in Oral Delivery of SN-38

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