Improved Interaction of Naproxen with Biomembrane Models by its Conjugation with Lipoamino Acids

机译：萘普生与脂膜氨基酸结合改善了萘普生与生物膜模型的相互作用

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The interaction of naproxen and its lipoamino acidderivatives with biomembrane models, represented bymultilamellar vesicles and monolayers made ofdimyristoylphosphatidylcholine, was investigated.Differential scanning calorimetry and Langmuir-Blodgetttechniques were used. The results show that theinteraction of naproxen with the biomembrane models wasenhanced by the conjugation with lipoamino acids.

机译：萘普生及其脂氨基酸的相互作用具有生物膜模型的衍生物，以多层囊泡和单层研究了二肉豆蔻酰基磷脂酰胆碱。差示扫描量热法和Langmuir-Blodgett 技术被使用。结果表明萘普生与生物膜模型的相互作用为通过与脂氨基酸结合而增强。

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《Annual meeting exposition of the Controlled Release Society》|2009年|p.1-2|共2页
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Francesco Castelli; Maria Grazia Sarpietro; Dorotea Micieli; Sara Ottimo; Maria Chiara Giuffrida; Livia Basile; Rosario Pignatello;
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中图分类药学;诊断学;
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专利

1. Enhancement of drug affinity for cell membranes by conjugation with lipoamino acids II. Experimental and computational evidence using biomembrane models. [J] . Pignatello R, Guccione S, Castelli F, International Journal of Pharmaceutics . 2006,第1a2期

机译：通过与脂氨基酸结合，增强对细胞膜的药物亲和力II。使用生物膜模型的实验和计算证据。
2. Enhancement of drug affinity for cell membranes by conjugation with lipoamino acids II. Experimental and computational evidence using biomembrane models. [J] . Pignatello R, Guccione S, Castelli F, International Journal of Pharmaceutics . 2006,第1a2期

机译：通过与脂氨基酸结合，增强对细胞膜的药物亲和力II。使用生物膜模型的实验和计算证据。
3. Lipophilic conjugates of methotrexate with glucosyl-lipoamino acids: calorimetric study of the interaction with a biomembrane model [J] . Pignatello R, Di Guardo L, Puleo A, Thermochimica Acta: An International Journal Concerned with the Broader Aspects of Thermochemistry and Its Applications to Chemical Problems . 2005,第1a2期

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4. Improved Interaction of Naproxen with Biomembrane Models by its Conjugation with Lipoamino Acids [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：用脂质氨基酸的缀合改善萘普酸与生物膜模型的相互作用
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机译：磷脂酰丝氨酸和含有鸟氨酸脂质的脂肪蛋白，脂质氨基酸结构的血凝素，及其在生物膜中的对照

Improved Interaction of Naproxen with Biomembrane Models by its Conjugation with Lipoamino Acids

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