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Which intracranial lesions would be suitable for fluoresce guided resection? A prospective review of 110 consecutive lesions

机译：哪种颅内病变适合进行荧光引导切除术？前瞻性回顾110连续病变

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Fluorescence guided surgical resection is based on the basic principle that photosensitizers are preferentially taken up and retained by cancer cells and the these sensitizers absorb light in one band of the light spectrum and release the energy as fluorescence that can be visualised in a different band of the spectrum. This study reports fluorescence outcome of 110 consecutive intracranial tumors to identify its potential benefits during fluorescence guided resection (FGR). The specificity of this technique was very high with no false positive results. Its sensitivity varied from 83.7% in brain lung metastasis to 85.7% in glioblastomas. A wide range of other intracranial tumors were also studied but the numbers in each of these subgroups were small to deduct its usefulness. However, grade III astrocytomas, primary cerebral lymphoma and meningiomas fluoresced very well in all patients. FGR would be therefore very useful aid during a wide range of intracranial tumor surgery with the advantages of specificity, high sensitivity and would not be affected by brain shift and tumor removal. The limitations of this technique were that the sensitivity was not 100% and it would be possible to miss 15% of tumors, blood can also obscure the fluorescence and it would be a problem in vascular tumors, and photo bleaching can reduce the fluorescence.
机译：荧光引导的手术切除基于以下基本原理：光敏剂优先被癌细胞吸收并保留，这些光敏剂吸收光谱某一波段的光，并以荧光的形式释放能量，该能量可以在不同光谱的波段中看到。光谱。这项研究报告了110个连续颅内肿瘤的荧光结果，以确定其在荧光引导切除术（FGR）期间的潜在益处。该技术的特异性很高，没有假阳性结果。其敏感性从脑肺转移的83.7％到胶质母细胞瘤的85.7％不等。还研究了范围广泛的其他颅内肿瘤，但是这些亚组中的每一个亚组的数量都很少，以降低其实用性。但是，所有患者的III级星形细胞瘤，原发性脑淋巴瘤和脑膜瘤均能很好地发荧光。因此，FGR将具有广泛的颅内肿瘤手术的特异性，高敏感性和不受脑移位和肿瘤清除的影响，将是非常有用的辅助工具。该技术的局限性在于灵敏度不是100％，有可能错过15％的肿瘤，血液也会使荧光模糊，这在血管肿瘤中是一个问题，光漂白可以减少荧光。

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