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首页> 外文会议>World congress of the International Photodynamic Association >Burn, freeze or photo-ablate? Comparative symptom profile in Barrett's dysplasia patients undergoing endoscopic ablation
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Burn, freeze or photo-ablate? Comparative symptom profile in Barrett's dysplasia patients undergoing endoscopic ablation

机译：燃烧，冻结或光消融？接受内镜消融的Barrett不典型增生患者的比较症状特征

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Background: There are few data available comparing endoscopic ablation methods for Barrett's esophagus with high-grade dysplasia (BE-HGD).Objective: To determine differences in symptoms and complications associated with endoscopic ablation. Design: Prospective observational study. Setting: Two tertiary care centers in USA. Patients: Consecutive patients with BE-HGDInterventions: In this pilot study, symptoms profile data were collected for BE-HGD patients among 3 endoscopic ablation methods: porfimer sodium photodynamic therapy, radiofrequency ablation and low-pressure liquid nitrogen spray cryotherapy.Main Outcome Measurements: Symptom profiles and complications from the procedures were assessed 1-8 weeks after treatment.Results: Ten BE-HGD patients were treated with each ablation modality (30 patients total; 25 men, median age: 69 years (range 53-81). All procedures were performed in the clinic setting and none required subsequent hospitalization. The most common symptoms among all therapies were chest pain, dysphagia and odynophagia. More patients (n=8) in the porfimer sodium photodynamic therapy group reported weight loss compared to radio-frequency ablactation (n=2) and cryotherapy (n=0). Four patients in the porfimer sodium photodynamic therapy group developed phototoxicity requiring medical treatment. Strictures, each requiring a single dilation, were found in radiofrequency ablactation (n=l) and porfimer sodium photodynamic therapy (n=2) patients. Limitations: Small sample size, non-randomized study.Conclusions: These three endoscopic therapies are associated with different types and severity of post-ablation symptoms and complications.
机译：背景：目前尚无可比的数据比较内镜消融方法对巴雷特食管伴高度不典型增生（BE-HGD）的作用。 目的：确定与内镜消融相关的症状和并发症的差异。设计：前瞻性观察研究。地点：美国的两个三级护理中心。患者：BE-HGD连续患者 干预措施：在该初步研究中，收集了BE-HGD患者三种内镜消融方法的症状特征数据：porfimer钠光动力疗法，射频消融和低压液氮喷雾冷冻疗法。 主要结果测量：在治疗后1-8周评估手术过程中的症状和并发症。 结果：每种消融方式均治疗了10名BE-HGD患者（共30例; 25名男性，中位年龄：69岁（范围53-81）。所有操作均在临床环境中进行，无需随后的住院治疗。所有疗法中的症状为胸痛，吞咽困难和吞咽痛。porfimer钠光动力疗法组报告的体重减轻比射频消融（n = 2）和冷冻疗法（n = 0）的患者多（n = 8）。4例porfimer钠光动力疗法组的光毒性需要药物治疗，射频消融术（n = l）和porfimer钠光动力疗法（n = 2）患者均发现狭窄，每个都需要单次扩张。随机研究。 结论：这三种内窥镜治疗与消融后症状和并发症的类型和严重程度有关。

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