Exploiting bacterial drug resistance: a single construct for the diagnosis and treatment of drug resistant infections

机译：开发细菌耐药性：用于诊断和治疗耐药性感染的单一构建体

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β-lactamase enzyme-activated photosensitizer (β-LEAP). We aim to exploit drug resistance mechanisms to selectively release photosensitizers (PSs) for a specific photodynamic antimicrobial effect and reduced host tissue damage. Consequently, the fluorescence emission intensity of the PSs increases and allows for the detection of enzyme activity. In this work we sought to evaluate β-LEAP for use as a sensitive molecular probe. We have reported the enzyme specific antibacterial action of β-LEAP. Here we report the use of β-LEAP for the rapid functional definition of a β-lactamase.

机译：β-内酰胺酶激活的光敏剂（β-LEAP）。我们旨在利用抗药性机制选择性释放光敏剂（PSs），以实现特定的光动力学抗菌效果并减少宿主组织损伤。因此，PS的荧光发射强度增加并且允许检测酶活性。在这项工作中，我们试图评估用作敏感分子探针的β-LEAP。我们已经报道了β-LEAP的酶特异性抗菌作用。在这里，我们报告了使用β-LEAP进行β-内酰胺酶的快速功能定义。

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《World congress of the International Photodynamic Association》|2009年|73806R.1-73806R.9|共9页
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Ulysses W. Sallum; Xiang Zheng; Sarika Verma; Tayyaba Hasan;
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中图分类其他科学技术在医学上的应用;应用光学;
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1. Exploiting a Bacterial Drug-Resistance Mechanism:A Light-Activated Construct for the Destruction of MRSA [J] . Xiang Zheng, Ulysses W.Solium, Sarika Verma Angewandte Chemie . 2009,第12期

机译：开发细菌耐药机制：破坏MRSA的光激活构造。
2. A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset [J] . Willy Chin, Guansheng Zhong, Qinqin Pu, Nature Communications . 2018,第1期

机译：消除多药耐药性细菌感染同时减轻耐药性发作的大分子方法
3. Targeting druggable enzymome by exploiting natural medicines: An in silico-in vitro integrated approach to combating multidrug resistance in bacterial infection [J] . Zang Ping, Gong Aijie, Zhang Peirong, Pharmaceutical Biology . 2016,第1a6期

机译：通过开发天然药物靶向可药物化酶组：一种计算机体外合成方法，以对抗细菌感染中的多药耐药性
4. Exploiting bacterial drug resistance: a single construct for the diagnosis and treatment of drug resistant infections [C] . World congress of the International Photodynamic Association . 2009

机译：利用细菌耐药性：一种用于抑制和治疗耐药性感染的单一构建体
5. Drug Resistance in Mycobacterium tuberculosis: An Investigation of Drug Transporter P-Glycoprotein and an Evaluation of Improved Diagnosis of Drug Resistant Tuberculosis in Cameroonian Pulmonary Tuberculosis Patients [D] . Abanda, Ngu Njei 2017

机译：结核分枝杆菌的耐药性：转运蛋白P-糖蛋白的调查和喀麦隆肺结核患者耐药性结核病改善诊断的评估
6. A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset [O] . Willy Chin, Guansheng Zhong, Qinqin Pu, -1

机译：消除多药耐药性细菌感染同时减轻耐药性发作的大分子方法
7. Figure 3: Relative growth rate of drug-resistant M. genitalium infections as a function of the proportion of resistant infections. Lines show growth rates for the best fit models for France, Denmark and Sweden, assuming a probability of de novo resistance during treatment of µ= 12. [O] . -1

机译：图3：耐药M.耐药性的相对生长速率作为抗性感染比例的函数。线条为法国，丹麦和瑞典的最佳拟合模型提供增长率，假设在μ= 12％的治疗过程中缺乏Novo抗性的可能性。
8. Identification of New Drug Targets in Multi-Drug Resistant Bacterial Infections. [R] . Gulick, A. M., Russo, T. A., Schultz, L. W., 2015

机译：多药耐药细菌感染新药靶点的鉴定。

Exploiting bacterial drug resistance: a single construct for the diagnosis and treatment of drug resistant infections

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