Genotoxic Effects of Microcystin-LR in Mammalian Cells

机译：微囊藻毒素-LR在哺乳动物细胞中的遗传毒性作用

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Microcystin-LR (MC-LR) is a heptapeptidic toxin produced by cyanobacteria. However, the genotoxic effects of MC-LR are still contrary. This study is focused on the DNA damage induced by MC-LR in human-hamster hybrid AL cell line, which is sensitive to various toxic factors. Our present data showed that MC-LR at a concentration of 0.1 mug/ml had slight effect on the celluar ATP contents and the colony formation of AL cells with either 1-, 3-, 7-, 15- or 30-day treatment. However, with 30-day treatment, the micronucleus frequency with 0.1 mug/ml was increased about 1.6-fold compared to the negative control. These data suggested that MC-LR was genotoxic to mammalian cells with minimal cytotoxicity.

机译：微囊藻毒素-LR（MC-LR）是蓝细菌产生的七肽毒素。但是，MC-LR的遗传毒性作用仍然相反。这项研究的重点是对人-仓鼠杂交AL细胞系中MC-LR诱导的DNA损伤，该损伤对多种毒性因子敏感。我们目前的数据表明，经过1天，3天，7天，15天或30天的处理，MC-LR的浓度为0.1马克/毫升对细胞的ATP含量和AL细胞的集落形成有轻微影响。但是，经过30天的治疗，与阴性对照相比，0.1杯/毫升的微核频率增加了约1.6倍。这些数据表明，MC-LR对哺乳动物细胞具有遗传毒性，而细胞毒性却最小。

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《Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009》|2009年|1-3|共3页
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Pei Huang; An Xu;
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DNA; biochemistry; cellular biophysics; genetics; microorganisms; molecular biophysics; proteins; toxicology; DNA damage; MC-LR; celluar ATP content; colony formation; cyanobacteria; cytotoxicity; genotoxic effect; heptapeptidic toxin; human-hamster hybrid AL cell line; mammalian cells; microcystin-LR; micronucleus frequency;

机译：DNA;生物化学;细胞生物物理学;遗传学;微生物;分子生物物理学;蛋白质;毒理学; DNA损伤; MC-LR;细胞ATP含量;菌落形成;蓝细菌;细胞毒性;遗传毒性作用;七肽毒素;人-仓鼠杂交AL细胞系;哺乳动物细胞;微囊藻毒素-LR;微核频率;

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2. Microcystin-LR induced cellular effects in mammalian and fish primary hepatocyte cultures and cell lines: a comparative study. [J] . Boaru DA, Dragos N, Schirmer K Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems . 2006,第2a3期

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3. Genotoxic and cytotoxic effects of Artemisia herba-alba on mammalian cells [J] . Abderrahman Salim M., Shbailat Seba Jamal Caryologia: Giornale de Citologia, Citosistematica e Citogenetica . 2014,第4期

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4. Genotoxic effects of Microcystin-LR in Mammalian cells [C] . Pei Huang, An Xu The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议）论文集 . 2009

机译：微囊藻毒素-LR对哺乳动物细胞的遗传毒性作用
5. The measurement of cell survival, and genotoxic endpoints in mammalian cells. [D] . Hook, Graham John. 1983

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6. Genotoxic Effects of Cylindrospermopsin Microcystin-LR and Their Binary Mixture in Human Hepatocellular Carcinoma (HepG2) Cell Line [O] . Leticia Díez-Quijada, Klara Hercog, Martina Štampar, 2020

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7. Comparative study of the cytotoxic effects of microcystin-LR in mammalian cell lines: Vero, HepG2, Caco2 and MDCK [O] . Menezes Carina 2009

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8. Relationships between Benzo(a)pyrene-DNA Adduct Levels and Genotoxic Effects in Mammalian Cells [R] . Arce, G. T. , Allen, J. W. , Doerr, C. L. , 1987

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Genotoxic Effects of Microcystin-LR in Mammalian Cells

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