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首页> 外文会议>Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 >Antitumor Activity of Escin in Mice Cervical Carcinoma U_(14) In Vivo and Human Cervical Carcinoma Hela Cell Line In Vitro
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Antitumor Activity of Escin in Mice Cervical Carcinoma U_(14) In Vivo and Human Cervical Carcinoma Hela Cell Line In Vitro

机译：Escin在小鼠宫颈癌U_（14）和人宫颈癌Hela细胞系中的抗肿瘤活性

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Pollution made cancer a major disease threatening people's health. In the search for new cancer drug treatments, natural products perform an essential role. Escin, a mixture of triterpene saponins extracted from Aesculus Wilsonii Rehd., was used to analyze the cell growth inhibitory effects and the induction of apoptosis in human cervical carcinoma Hela cancer cell line in vitro. The results of MTT cell viability assay showed that escin could induce significant concentration-dependent and time-dependent inhibition of cell growth, and the cell cycle was arrested at G1/S phase in the escin-treated cells. Apoptosis were detected and assessed by Acridine Orange/Ethidium Bromide Staining and Flow Cytometry. The antitumor efficacy of escin on mice cervical carcinoma U_(14) in vivo was investigated, at dose of 2.8 mg/kg escin had rather high inhibition ratio(43.5%) on U_(14) tumor growth.
机译：污染使癌症成为威胁人们健康的主要疾病。在寻找新的癌症药物治疗中，天然产物起着至关重要的作用。 Escin是从七叶树七叶树提取的三萜皂苷的混合物，用于分析人宫颈癌Hela癌细胞体外的细胞生长抑制作用和诱导细胞凋亡。 MTT细胞活力测定的结果表明，七叶皂苷可明显抑制浓度和时间依赖性的细胞生长，且细胞周期被阻滞于七叶皂苷处理过的细胞的G 1 / S期。 。通过A啶橙/溴化乙锭染色和流式细胞术检测并评估细胞凋亡。研究了七叶红素对小鼠宫颈癌U_（14）的体内抗肿瘤作用，剂量为2.8 mg / kg七叶红素对U_（14）肿瘤的生长具有较高的抑制率（43.5％）。

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