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首页> 外文会议>Proceedings of the IEEE 4th International Conference on Nano/Molecular Medicine and Engineering >Observation of angiotensin II-induced changes in tubular epithelial cells utilizing AFM: Angiotensin II-induced changes in tubular cells
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Observation of angiotensin II-induced changes in tubular epithelial cells utilizing AFM: Angiotensin II-induced changes in tubular cells

机译：利用AFM观察血管紧张素II诱导的肾小管上皮细胞的变化：血管紧张素II诱导的肾小管细胞的变化

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Atomic force microscopy (AFM) has become an important device to visualize various cells and biological materials for non-invasive imaging. The major advantage of AFM compared to the conventional optical and electron microscopes is its convenience. Sample preparation for AFM does not need special coating or vacuum as a procedure. AFM can detect samples even under the aqueous condition. Although the AFM is originally used to obtain surface topography of sample, it can measure precisely the interactions between its probe tip and the sample surface from force-distance measurements. Epithelial-to-mesenchymal transformation of tubular cells into myofibroblastic phenotype is an important mediator of renal injury in chronic nephropathy. It is generally known that angiotensin II (Ang II) plays a direct profibrotic role in the kidney, but the mechanism is unclear. In this study, we observed structural and mechanical changes in tubular epithelial cell after Ang II treatment using AFM.
机译：原子力显微镜（AFM）已成为可视化各种细胞和生物材料以进行非侵入式成像的重要设备。与传统的光学和电子显微镜相比，AFM的主要优势在于其便利性。 AFM的样品制备不需要特殊的涂层或真空。即使在水性条件下，AFM也可以检测样品。尽管AFM最初用于获得样品的表面形貌，但它可以通过力距测量精确地测量其探针尖端与样品表面之间的相互作用。肾小管上皮细胞向间充质转化为肌纤维母细胞表型是慢性肾病中肾脏损伤的重要介质。众所周知，血管紧张素II（Ang II）在肾脏中具有直接的纤维化作用，但机制尚不清楚。在这项研究中，我们观察到使用AFM的Ang II治疗后肾小管上皮细胞的结构和机械变化。

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