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首页> 外文会议>32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Control of action potential duration alternans in canine ventricular tissue
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Control of action potential duration alternans in canine ventricular tissue

机译：犬心室组织中动作电位持续时间交替的控制

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Cardiac action potential duration alternans is characterized by a beat-to-beat alternation in action potential waveform. Its presence has been putatively linked to the onset of lethal cardiac arrhythmias. Previous studies, which have been limited to cardiac Purkinje fibers, have shown that closed-loop alternans control techniques, which apply a succession of externally administered cycle perturbations, provide ineffectual spatial alternans elimination. A more complete understanding of alternans control in the more clinically relevant ventricular tissue is needed. Here, we study the spatial dynamics of alternans and alternans control in arterially perfused canine right ventricular preparations using optical mapping. We quantified the spatial efficacy of alternans control across 2.5 cm of tissue, focusing primarily on differences in spatial control within several sub-regions of tissue. Our results provide a basis for future investigations into multi-electrode-based control interventions of alternans in cardiac tissue.
机译：心脏动作电位持续时间交替的特征在于动作电位波形的逐跳交替。它的存在被认为与致命性心律不齐的发作有关。以前仅限于心脏Purkinje纤维的研究表明，闭环的交替蛋白控制技术采用了一系列外部施加的周期扰动，无法有效地消除空间交替蛋白。需要对更临床相关的心室组织中的交替蛋白控制有一个更全面的了解。在这里，我们使用光学映射研究动脉灌注的犬右心室制剂中交替蛋白和交替蛋白控制的空间动力学。我们量化了跨2.5厘米组织的交替蛋白控制的空间功效，主要集中于组织几个子区域内空间控制的差异。我们的结果为今后对心脏组织中交替素的基于多电极的控制干预研究提供了基础。

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