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首页> 外文会议>Congress of the International Radiation Protection Association;IRPA 12 >Evaluation of radioprotection properties of propolis by chromosomal alterations, cell proliferation kinetics, mitotic index and sister chromatid exchange.
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Evaluation of radioprotection properties of propolis by chromosomal alterations, cell proliferation kinetics, mitotic index and sister chromatid exchange.

机译：通过染色体改变，细胞增殖动力学，有丝分裂指数和姐妹染色单体交换评估蜂胶的辐射防护特性。

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A consequence of ionizing radiation is the induction of chromosomal alterations. This causalityrelation involves that chromosomal alterations can be considered a good indicator of the radiological damage.Some chemical agents can modulate the tissue response to radiation. These compounds are useful because theyshow certain selectivity, protecting the healthy tissues (radioprotectors) or increasing the sensibility of tissues toradiations (radiosensibilizators). Propolis substance has showed radioprotection properties which are performedin the following study. Propolis is a product of extraordinary interest for both medicine and pharmaceuticalindustry, since it is assumed to show diverse beneficial health effects. Among many other attributes of EEP(propolis ethanolic extract), it exhibits antioxidant and radical free scavenger properties. In a previous study,human peripheral blood lymphocytes were exposed to 2 Gy of γ rays in presence and absence of EEP, and theanalysis showed a reduction in the frequency of dicentrics and rings, with a maximum protection of 50%. Theproposed concentration for radioprotection would be between 120-500 μg·ml~(-1). The cytotoxic effect has beenevaluated analyzing the EEP effect in the cellular division cycle. Propolis ethanolic extract (EEP) has beenobtained and samples of peripheral blood have been cultured in the presence of increasing concentrations of EEP.In order to quantify it, two indexes have been used, the mitotic index and cell proliferation index. For bothindexes the cytotoxic effect takes place from 750 μg·ml-1 concentrations onwards. Similar results were obtainedfor the analysis of chromosomal aberrations. Finally, propolis effect in lymphocytes by sister chromatid exchangetest has been presented for higher concentrations of EEP.
机译：电离辐射的结果是引起染色体改变。这种因果关系 这种关系涉及染色体改变可以被认为是放射损伤的良好指标。 一些化学试剂可以调节组织对辐射的反应。这些化合物之所以有用，是因为它们 表现出一定的选择性，保护健康的组织（放射防护剂）或增加组织的敏感性 辐射（radiosensibilizators）。蜂胶物质显示出了防辐射性能 在下面的研究中。蜂胶是医学和制药界非常感兴趣的产品 因为它被认为具有多种有益健康的功效，因此被认为是一种工业。 EEP的许多其他属性 （蜂胶乙醇提取物），它具有抗氧化剂和自由基清除剂的性能。在先前的研究中 在有无EEP的情况下，人外周血淋巴细胞暴露于2 Gy的γ射线，并且 分析表明，双心轮和环的频率降低了，最大保护率达到了50％。这 放射防护的建议浓度为120-500μg·ml〜（-1）。细胞毒性作用已经 评估了在细胞分裂周期中的EEP效应分析。蜂胶乙醇提取物（EEP）已被 在增加的EEP浓度下培养获得的血样和外周血样品。 为了量化它，使用了两个指数，即有丝分裂指数和细胞增殖指数。对彼此而言 指标从750μg·ml-1浓度开始发生细胞毒性作用。获得了相似的结果 用于分析染色体畸变。最后，蜂胶通过姐妹染色单体交换对淋巴细胞产生作用 已经提出了针对较高EEP浓度的测试。

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