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首页> 外文会议>International Marine Biotechnology Conference >Dieckol from Ecklonia cavaRegulates Invasion of Human Fibrosarcoma Cells andModulates MMP-2 and MMP-9 Expression via NF-κB Pathway
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Dieckol from Ecklonia cavaRegulates Invasion of Human Fibrosarcoma Cells andModulates MMP-2 and MMP-9 Expression via NF-κB Pathway

机译：Ecklonia cava的Dieckol调节人纤维肉瘤细胞的侵袭并通过NF-κB途径调节MMP-2和MMP-9表达

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@@ The matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, as well as in the disease processes such as arthritis and cancer metastasis. In the present study, dieckol was obtained with high yield from marine brown alga Ecklonia cava (EC), and its e.ect was assessed on the expression of MMP-2 and -9 and morphological changes in human fibrosarcoma cell line (HT1080). Dieckol inhibited the expression of MMP-2 and -9 in a dosedependentmanner and also suppressed the cell invasion and the cytomorphology in 3D culture systemon HT1080 cells.Moreover, dieckol may influence nuclear factor kappa B (NF-κB) pathway without obvious influence on activator protein-1 (AP-1) pathway and tissue inhibitor of metalloproteinases (TIMPs). In conclusion, dieckol could significantly suppress MMP-2 and -9 expression and alter cytomorphology of HT1080 cell line via NF-κB pathway.
机译：基质金属蛋白酶（MMP）家族参与正常生理过程以及诸如关节炎和癌症转移的疾病过程中的细胞外基质的分解。在本研究中，dieckol是从海洋褐藻Ecklonia cava（EC）中以高收率获得的，并且通过检测人纤维肉瘤细胞系（HT1080）中MMP-2和-9的表达以及形态变化来评估其效果。 Dieckol以剂量依赖的方式抑制MMP-2和-9的表达，并抑制HT1080细胞在3D培养系统中的细胞侵袭和细胞形态学;此外，dieckol可能影响核因子κB（NF-κB）途径而对激活剂没有明显影响蛋白-1（AP-1）途径和金属蛋白酶组织抑制剂（TIMPs）。结论：地eckol可通过NF-κB途径显着抑制HT1080细胞系MMP-2和-9的表达，并改变细胞形态。

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