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首页> 外文会议>Annual meeting exposition of the Controlled Release Society >Enhanced Anti-tumor Effect of 5-Fluorouracil-loaded Thermoresponsive Conjugated Linoleic Acid-incorporated Poloxamer Hydrogel on Metastatic Colon Cancer Models
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Enhanced Anti-tumor Effect of 5-Fluorouracil-loaded Thermoresponsive Conjugated Linoleic Acid-incorporated Poloxamer Hydrogel on Metastatic Colon Cancer Models

机译：5-氟尿嘧啶负载热响应共轭亚油酸的泊洛沙姆水凝胶对转移性结肠癌模型的增强抗肿瘤作用。

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摘要

Conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) is an effective drug delivery system with numerous advantages and has an anticancer activity. 5-FU administered in Plu-CLA hydrogel (P-FU) led to significant enhancement of tumor growth suppression and cellular apoptosis. Moreover, growth of hepatic and intraperitoneal metastases in vivo was significantly reduced in mice treated with P-FU. . Therefore, Plu-CLA could be a potential intraperitoneal carrier for hydrophilic 5-FU for the effective treatment of metastatic colon cancer.
机译：共轭亚油酸偶联的Pluronic F127（Plu-CLA）是一种有效的药物输送系统，具有许多优点，并且具有抗癌活性。在Plu-CLA水凝胶（P-FU）中施用的5-FU可显着增强肿瘤生长抑制和细胞凋亡。此外，在用P-FU治疗的小鼠体内，肝和腹膜内转移的生长明显减少。 。因此，Plu-CLA可能是亲水性5-FU潜在的腹膜内载体，可有效治疗转移性结肠癌。

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