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Self-assembled Nanocarriers for Co-delivery of Drug and Gene

机译：自组装的纳米载体，用于药物和基因的共同传递

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摘要

Novel micellar nanocarriers for drug and gene delivery were engineered utilizing polyethyleneglycol-polyethylenimine-phosphatidylethanolamine (PEG-PEI-PE)conjugates. The amphiphilic polymers were synthesized by coupling different quantities of PE to low molecular weight PEI followed by conjugation with PEG. These conjugates were able to effectively complex DNA, assemble into micellar nanocarriers, protect DNA from degradation by nuclease, and exhibited low toxicity. Such micellar nanocarriers could be of great potential as dual carriers of gene and anticancer drug.
机译：利用聚乙二醇-聚乙烯亚胺-磷脂酰乙醇胺（PEG-PEI-PE）设计了用于药物和基因递送的新型胶束纳米载体 共轭物。通过将不同数量的PE偶联至低分子量PEI，然后与PEG偶联来合成两亲性聚合物。这些结合物能够有效地复合DNA，组装成胶束纳米载体，保护DNA不受核酸酶降解，并显示出低毒性。这种胶束纳米载体作为基因和抗癌药物的双重载体具有巨大的潜力。

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